Reactome | CLK is phosphorylated by DCO

CLK is phosphorylated by DCO

Stable Identifier

R-DME-432513

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nucleoplasm

ReviewStatus

5/5

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Clock (CLK) protein is now phosphorylated on unknown serine/threonine residues by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO). It is not yet known whether other kinases are involved in phosphorylating CLK, potentially brought to there via interactions with DCO and Period (PER) acting as scaffolding proteins. There is also evidence from mammalian systems that chromatin remodelling factors are brought in by the PER scaffold and are responsible for a sustained state of transcription inhibition in these genes.

Literature References

PubMed ID	Title	Journal	Year
18474612	Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications Hardin, PE, Taylor, P	Mol Cell Biol	2008
16543224	PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription Dauwalder, B, Hardin, PE, Zheng, H, Houl, JH, Yu, W	Genes Dev	2006
16603629	Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein Kim, EY, Edery, I	Proc Natl Acad Sci U S A	2006
19139270	DOUBLETIME plays a noncatalytic role to mediate CLOCK phosphorylation and repress CLOCK-dependent transcription within the Drosophila circadian clock Price, JL, Hardin, PE, Zheng, H, Yu, W	Mol Cell Biol	2009
17452449	A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function Kim, EY, Hardin, PE, Edery, I, Ko, HW, Yu, W	Mol Cell Biol	2007

Participants

Input

Output

Participates

as an event of

Transcription repression by PER and activation by PDP1 (Drosophila melanogaster)

Catalyst Activity

protein serine/threonine kinase activity of Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm]

Physical Entity

Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO [nucleoplasm] (Drosophila melanogaster)

Activity

protein serine/threonine kinase activity (GO:0004674)

Authored

Williams, MG (2009-08-13)

Reviewed

Edery, I (2010-07-06)

Created

Williams, MG (2009-08-14)

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