Reactome | phospho-p38b [nucleoplasm]

phospho-p38b [nucleoplasm]

Stable Identifier

R-DME-446227

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

p-T180,Y182-MAPK14, O61443

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - Regulation of TP53 Activity (Drosophila melanogaster)
        
        Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
        
        MAPKAPK5 phosphorylates TP53 (Drosophila melanogaster)
        
        phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Drosophila melanogaster)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of p-T180,Y182-MAPK14 [nucleoplasm] (Drosophila melanogaster)
        
        phospho-p38b [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by NTRKs (Drosophila melanogaster)
    - Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
      - Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
        
        ERK/MAPK targets (Drosophila melanogaster)
        
        p38MAPK phosphorylates MSK1 (Drosophila melanogaster)
        
        p-p38 MAPK alpha/beta [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of p-T180,Y182-MAPK14 [nucleoplasm] (Drosophila melanogaster)
        
        phospho-p38b [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O61443

Gene Names

p38b

Reference Genes

BioGPS Gene:34780 p38b

CTD Gene:34780 p38b

ENSEMBL:FBgn0024846

Flybase:FBgn0024846

KEGG Gene (Drosophila melanogaster):Dmel_CG7393 p38b

Monarch:34780 p38b

NCBI Gene:34780 p38b

Reference Transcript

RefSeq:NM_058013.5 p38b

Other Identifiers

154281_at

1622982_at

34780

GO:0000165

GO:0000166

GO:0001934

GO:0002376

GO:0003007

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0006464

GO:0006468

GO:0006950

GO:0006955

GO:0007010

GO:0007165

GO:0007267

GO:0007476

GO:0007568

GO:0007623

GO:0008150

GO:0008340

GO:0009408

GO:0009617

GO:0009651

GO:0010468

GO:0016301

GO:0016310

GO:0016740

GO:0021700

GO:0022607

GO:0030510

GO:0030838

GO:0034330

GO:0034614

GO:0035331

GO:0035556

GO:0038001

GO:0040007

GO:0040018

GO:0042542

GO:0042594

GO:0042742

GO:0043167

GO:0043226

GO:0043473

GO:0045088

GO:0045793

GO:0048082

GO:0048856

GO:0050832

GO:0065003

GO:0071243

GO:0071276

GO:0106310

GO:0106311

GO:1900407

GO:2000331

Participates

as a member of

Homologues of p-T180,Y182-MAPK14 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

p38b [nucleoplasm]

p38b [secretory granule lumen]

p38b [extracellular region]

p38b [ficolin-1-rich granule lumen]

phospho-p38b [cytosol]

p38b [cytosol]

p38b [nucleoplasm]

p38b [cytosol]

phospho-p38b [cytosol]

phospho-p38b [nucleoplasm]

Inferred From

p-T180,Y182-MAPK14 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 180 (in Homo sapiens)

Coordinate

180

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 182 (in Homo sapiens)

Coordinate

182

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_477361.1

Flybase

FBgn0024846

PRO

O61443

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