Reactome | HERC2 [nucleoplasm]

HERC2 [nucleoplasm]

Stable Identifier

R-DME-4551680

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

HERC2, Q9VR91

Locations in the PathwayBrowser for interactor UniProt:Q9VLS7

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External Reference Information

External Reference

UniProt:Q9VR91

Gene Names

HERC2

Reference Genes

BioGPS Gene:33035 HERC2

ENSEMBL:FBgn0031107

Flybase:FBgn0031107

KEGG Gene (Drosophila melanogaster):Dmel_CG11734 HERC2

Monarch:33035 HERC2

NCBI Gene:33035 HERC2

UCSC:Q9VR91 HERC2

Reference Transcript

RefSeq:NM_134544.3 HERC2

Other Identifiers

145422_at

1629145_at

33035

GO:0003824

GO:0004842

GO:0005515

GO:0005575

GO:0005634

GO:0005737

GO:0005814

GO:0005815

GO:0005856

GO:0009966

GO:0016020

GO:0016567

GO:0016740

GO:0023052

GO:0036211

GO:0043226

GO:0046872

GO:0061630

GO:0140096

Participates

as an input of

HERC2 and PIAS4 are recruited to DNA DSBs (Drosophila melanogaster)

as a component of

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

HERC2 [cytosol]

phospho-HERC2 [nucleoplasm]

Inferred From

HERC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_608388.2

Flybase

FBgn0031107

OpenTargets

ENSG00000128731

PRO

Q9VR91

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34082	2	Fas2 [extracellular region] (R-DME-8941043) Fas2 [plasma membrane] (R-DME-8940745)	0.597	3
UniProt:M9NFI9 M9NFI9			0.462	2
UniProt:Q9VDY1	1	INO80 [nucleoplasm] (R-DME-5688910)	0.462	2
UniProt:Q9VLS7	3	PAPLA1 [cytosol] (R-DME-5216217) PAPLA1 [COPII-coated ER to Golgi transport vesicle] (R-DME-5688153) PAPLA1 [cytosol] (R-DME-5688156)	0.462	2

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