Reactome | CG15158 [nucleoplasm]

CG15158 [nucleoplasm]

Stable Identifier

R-DME-4570490-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

CETN2, Q8T415

Locations in the PathwayBrowser

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DNA Repair (Drosophila melanogaster)

- Nucleotide Excision Repair (Drosophila melanogaster)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
    - DNA Damage Recognition in GG-NER (Drosophila melanogaster)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - UV-DDB ubiquitinates XPC (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - XPC binds RAD23 and CETN2 (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Drosophila melanogaster)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
    - Formation of Incision Complex in GG-NER (Drosophila melanogaster)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - Recruitment of XPA and release of CAK (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - SUMOylation of XPC (Drosophila melanogaster)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
      - TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Drosophila melanogaster)
        
        Ub:XPC:RAD23:CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - SUMOylation (Drosophila melanogaster)
    - SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
      - SUMOylation of DNA damage response and repair proteins (Drosophila melanogaster)
        
        CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Drosophila melanogaster)
        
        Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)
        
        CG15158 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q8T415

Gene Names

CG15158

Reference Genes

BioGPS Gene:318949 CG15158

ENSEMBL:FBgn0051802

Flybase:FBgn0051802

KEGG Gene (Drosophila melanogaster):Dmel_CG31802 CG15158

Monarch:318949 CG15158

NCBI Gene:318949 CG15158

UCSC:Q8T415 CG15158

Reference Transcript

RefSeq:NM_165246.2 CG15158

Other Identifiers

146434_at

1638395_at

318949

GO:0000278

GO:0005509

GO:0005813

GO:0005814

GO:0005815

GO:0005856

GO:0007010

GO:0007099

GO:0043226

Participates

as a member of

Homologues of CETN2 [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

CG15158 [nucleoplasm]

CG15158 [cytosol]

Inferred From

CETN2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_724103.1

Flybase

FBgn0051802

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