Reactome | Dred [cytosol]

Dred [cytosol]

Stable Identifier

R-DME-535580

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

DCTN1, Q7JQV2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
      - Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Asparagine N-linked glycosylation (Drosophila melanogaster)
    - Transport to the Golgi and subsequent modification (Drosophila melanogaster)
      - ER to Golgi Anterograde Transport (Drosophila melanogaster)
        
        COPI-mediated anterograde transport (Drosophila melanogaster)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - ER to Golgi Anterograde Transport (Drosophila melanogaster)
    - COPI-mediated anterograde transport (Drosophila melanogaster)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
    - Golgi-to-ER retrograde transport (Drosophila melanogaster)
      - COPI-independent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynactin [cytosol] (Drosophila melanogaster)
        
        Dynactin arm [cytosol] (Drosophila melanogaster)
        
        DCTN1 dimer [cytosol] (Drosophila melanogaster)
        
        Dred [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7JQV2

Gene Names

Dred

Reference Genes

BioGPS Gene:40124 Dred

ENSEMBL:FBgn0036882

FlyBase:FBgn0036882

KEGG:dme:Dmel_CG9279 Dred

Monarch:40124 Dred

NCBI Gene:40124 Dred

UCSC:Q7JQV2 Dred

Reference Transcript

Other Identifiers

142968_at

151737_at

152213_at

1630823_at

1635802_s_at

40124

GO:0000132

GO:0000776

GO:0000922

GO:0005814

GO:0005819

GO:0005856

GO:0005869

GO:0005874

GO:0005875

GO:0006886

GO:0007010

GO:0007097

GO:0030286

GO:0030424

GO:0043226

GO:0051301

Participates

as a component of

DCTN1 dimer [cytosol] (Drosophila melanogaster)

Inferred From

DCTN1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_649124.1, NP_730426.1

ENSEMBL

FBgn0036882, FBtr0332758, FBtr0074976, FBpp0074744, FBpp0304997

FlyBase

FBgn0036882

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q24114 dally	20	DALLY [plasma membrane] (R-DME-206243) dally [plasma membrane] (R-DME-2076637) dally [plasma membrane] (R-DME-2076656) dally [plasma membrane] (R-DME-2076622) dally [plasma membrane] (R-DME-2076660) dally [plasma membrane] (R-DME-2076650) dally [plasma membrane] (R-DME-2076669) dally [endoplasmic reticulum lumen] (R-DME-8956735) phospho-dally [endoplasmic reticulum lumen] (R-DME-8956894) dally [Golgi lumen] (R-DME-2064202) dally [Golgi lumen] (R-DME-2063987) dally [Golgi lumen] (R-DME-2064021) dally [Golgi lumen] (R-DME-2054100) dally [Golgi lumen] (R-DME-2064012) dally [Golgi lumen] (R-DME-2076404) dally [Golgi lumen] (R-DME-2076554) dally [Golgi lumen] (R-DME-2076550) dally [Golgi lumen] (R-DME-2076507) dally [Golgi lumen] (R-DME-2076413) dally [Golgi lumen] (R-DME-2076471)	0.462	2

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