Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO

Stable Identifier
R-DME-538822
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.
Literature References
PubMed ID Title Journal Year
17575052 Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)

Fang, Y, Sehgal, A, Sathyanarayanan, S

Genes Dev 2007
18593878 The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

Vanselow, JT, Edery, I, Kramer, A, Chiu, JC

Genes Dev 2008
14980226 Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A

Xiao, R, Sehgal, A, Sathyanarayanan, S, Zheng, X

Cell 2004
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PP2A [cytosol]

Authored
Reviewed
Created
Cite Us!