PP1 binds to phosphorylated TIM in complex with PER

Stable Identifier
R-DME-538824
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).
Literature References
PubMed ID Title Journal Year
17575052 Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)

Fang, Y, Sehgal, A, Sathyanarayanan, S

Genes Dev 2007
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