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FEN1 [nucleoplasm]
Stable Identifier
R-DME-54745
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
Q7K7A9
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA strand elongation (Drosophila melanogaster)
Lagging Strand Synthesis (Drosophila melanogaster)
Processive synthesis on the lagging strand (Drosophila melanogaster)
Removal of the Flap Intermediate (Drosophila melanogaster)
Removal of remaining Flap (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
PCNA-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through MMEJ (alt-NHEJ) (Drosophila melanogaster)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA strand elongation (Drosophila melanogaster)
Lagging Strand Synthesis (Drosophila melanogaster)
Processive synthesis on the lagging strand (Drosophila melanogaster)
Removal of the Flap Intermediate (Drosophila melanogaster)
Removal of remaining Flap (Drosophila melanogaster)
FEN1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7K7A9
Reference Genes
BioGPS Gene:36887
ENSEMBL:FBgn0025832
FlyBase:FBgn0025832
KEGG:dme:Dmel_CG8648
Monarch:36887
NCBI Gene:36887
UCSC:Q7K7A9
Reference Transcript
RefSeq:NM_079041.2
Other Identifiers
144102_at
1624557_at
36887
GO:0000287
GO:0003677
GO:0003824
GO:0004518
GO:0004519
GO:0004523
GO:0004527
GO:0005634
GO:0005654
GO:0005730
GO:0005739
GO:0006260
GO:0006281
GO:0006284
GO:0008409
GO:0016787
GO:0016788
GO:0017108
GO:0030145
GO:0043137
GO:0043226
GO:0046872
GO:0140097
GO:0140098
Participates
as a component of
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Drosophila melanogaster)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Drosophila melanogaster)
as an output of
FEN1 cleaves displaced ssDNA flaps during MMEJ (Drosophila melanogaster)
as an input of
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Drosophila melanogaster)
Inferred From
FEN1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_523765.1
ENSEMBL
FBtr0087075
,
FBpp0086223
PRO
Q7K7A9
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