Reactome | mus101 [nucleoplasm]

mus101 [nucleoplasm]

Stable Identifier

R-DME-5684878

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

TOPBP1, Q9VY97

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G2/M Checkpoints (Drosophila melanogaster)
    - G2/M DNA damage checkpoint (Drosophila melanogaster)
      - ATR phosphorylates TP53 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)

DNA Repair (Drosophila melanogaster)

- DNA Double-Strand Break Repair (Drosophila melanogaster)
  - Homology Directed Repair (Drosophila melanogaster)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
      - Processing of DNA double-strand break ends (Drosophila melanogaster)
        
        ATR phosphorylates RPA2 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)
        
        Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)
        
        CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - Regulation of TP53 Activity (Drosophila melanogaster)
        
        Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
        
        ATR phosphorylates TP53 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        mus101 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VY97

Gene Names

mus101

Reference Genes

BioGPS Gene:48309 mus101

CTD Gene:48309 mus101

ENSEMBL:FBgn0002878

Flybase:FBgn0002878

KEGG Gene (Drosophila melanogaster):Dmel_CG11156 mus101

Monarch:48309 mus101

NCBI Gene:48309 mus101

UCSC:Q9VY97 mus101

Reference Transcript

RefSeq:NM_080170.4 mus101

Other Identifiers

145028_at

1635302_at

48309

GO:0000278

GO:0006260

GO:0006270

GO:0007095

GO:0023052

GO:0033314

Participates

as a component of

Inferred From

TOPBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524909.1

Flybase

FBgn0002878