Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Sirt4 [mitochondrial matrix]
Stable Identifier
R-DME-5687775
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
mitochondrial matrix
Synonyms
SIRT4, Q8IRR5
Locations in the PathwayBrowser
Expand all
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
SIRT4 cleaves lipoyl from DLAT (Drosophila melanogaster)
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Sirt4 [mitochondrial matrix] (Drosophila melanogaster)
Organelle biogenesis and maintenance (Drosophila melanogaster)
Mitochondrial biogenesis (Drosophila melanogaster)
Transcriptional activation of mitochondrial biogenesis (Drosophila melanogaster)
SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Sirt4 [mitochondrial matrix] (Drosophila melanogaster)
Sirt4 [mitochondrial matrix] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q8IRR5
Gene Names
Sirt4
Reference Genes
BioGPS Gene:31480 Sirt4
ENSEMBL:FBgn0029783
FlyBase:FBgn0029783
KEGG:dme:Dmel_CG3187 Sirt4
Monarch:31480 Sirt4
NCBI Gene:31480 Sirt4
UCSC:Q8IRR5 Sirt4
Reference Transcript
RefSeq:NM_167042.3 Sirt4
RefSeq:NM_132013.3 Sirt4
RefSeq:NM_167041.3 Sirt4
Other Identifiers
144534_at
1623881_s_at
31480
GO:0003824
GO:0003950
GO:0004407
GO:0005739
GO:0005759
GO:0006325
GO:0008270
GO:0008340
GO:0009267
GO:0016740
GO:0017136
GO:0034979
GO:0040029
GO:0046872
GO:0051287
GO:0070403
GO:0140096
Participates
as a component of
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Inferred From
SIRT4 [mitochondrial matrix]
(Homo sapiens)
Cross References
RefSeq
NP_572241.2
,
NP_727014.2
,
NP_727013.2
ENSEMBL
FBtr0070852
,
FBgn0029783
,
FBpp0070817
IntEnz
2.3.1.286
FlyBase
FBgn0029783
PRO
Q8IRR5
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text