Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Dsor1 [cytosol]
Stable Identifier
R-DME-59504
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
MAP2K2, Q24324
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
MAP2K and MAPK activation (Drosophila melanogaster)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks and MAPKs bind to the activated RAF complex (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
RAF phosphorylates MAP2K dimer (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by NTRKs (Drosophila melanogaster)
Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
Signalling to ERKs (Drosophila melanogaster)
Prolonged ERK activation events (Drosophila melanogaster)
Frs2-mediated activation (Drosophila melanogaster)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Drosophila melanogaster)
MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
Dsor1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24324 Dsor1
Gene Names
Dsor1, CG15793
Chain
chain:1-396
Reference Genes
BioGPS Gene:31872 Dsor1
KEGG Gene (Drosophila melanogaster):Dmel_CG15793 Dsor1
Monarch:31872 Dsor1
NCBI Gene:31872 Dsor1
Reference Transcript
RefSeq:NM_078543.4 Dsor1
RefSeq:NM_001298115.1 Dsor1
Other Identifiers
154939_at
1626006_at
31872
GO:0000003
GO:0000165
GO:0000166
GO:0000187
GO:0000278
GO:0000793
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005694
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007049
GO:0007095
GO:0007165
GO:0007173
GO:0007298
GO:0007362
GO:0007430
GO:0007465
GO:0007568
GO:0007623
GO:0008150
GO:0008286
GO:0008293
GO:0008340
GO:0008543
GO:0009790
GO:0009953
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019899
GO:0019900
GO:0030154
GO:0033314
GO:0040011
GO:0042386
GO:0042461
GO:0043167
GO:0043226
GO:0045500
GO:0048010
GO:0048856
GO:0048870
GO:0051607
GO:0070371
GO:0071481
GO:0106310
Participates
as a component of
MAP2K2 dimer [cytosol] (Drosophila melanogaster)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Drosophila melanogaster)
Other forms of this molecule
DSOR1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
phospho-Dsor1 [cytosol]
Inferred From
MAP2K2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001285044.1
,
NP_511098.1
Flybase
FBgn0010269
PRO
Q24324
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11346 Raf
20
Phospho PHL [plasma membrane]
(R-DME-205859)
PHL [cytosol]
(R-DME-205713)
Raf [cytosol]
(R-DME-167205)
phospho-Raf [cytosol]
(R-DME-5624465)
phospho-Raf [cytosol]
(R-DME-5624469)
phospho-Raf [plasma membrane]
(R-DME-206222)
phospho-Raf [plasma membrane]
(R-DME-5675420)
phospho-Raf [plasma membrane]
(R-DME-5675199)
phospho-Raf [plasma membrane]
(R-DME-5675193)
phospho-Raf [cytosol]
(R-DME-5672646)
phospho-Raf [cytosol]
(R-DME-5672676)
phospho-Raf [cytosol]
(R-DME-5672664)
phospho-Raf [cytosol]
(R-DME-5672673)
phospho-Raf [plasma membrane]
(R-DME-5672679)
phospho-Raf [plasma membrane]
(R-DME-5672648)
phospho-Raf [plasma membrane]
(R-DME-5672665)
phospho-Raf [cytosol]
(R-DME-5672681)
phospho-Raf [cytosol]
(R-DME-206028)
Raf [cytosol]
(R-DME-167224)
phospho-Raf [cytosol]
(R-DME-5672639)
0.667
5
UniProt:P40417
8
rl [azurophil granule lumen]
(R-DME-6799225)
rl [extracellular region]
(R-DME-6806250)
rl [ficolin-1-rich granule lumen]
(R-DME-6800964)
phospho-rl [cytosol]
(R-DME-9635773)
rl [nucleoplasm]
(R-DME-199960)
rl [cytosol]
(R-DME-59282)
phospho-rl [cytosol]
(R-DME-109853)
phospho-rl [nucleoplasm]
(R-DME-112354)
0.534
3
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text