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XPA [nucleoplasm]
Stable Identifier
R-DME-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
P28518
Locations in the PathwayBrowser
Expand all
DNA Repair (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Dual Incision in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Formation of Incision Complex in GG-NER (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Recruitment of XPA and release of CAK (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
SUMOylation of XPC (Drosophila melanogaster)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Drosophila melanogaster)
XPA [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P28518
Reference Genes
BioGPS Gene:31357
CTD Gene:31357
ENSEMBL:FBgn0004832
FlyBase:FBgn0004832
KEGG:dme:Dmel_CG6358
Monarch:31357
NCBI Gene:31357
UCSC:P28518
Reference Transcript
RefSeq:NM_057518.4
Other Identifiers
143515_at
1623485_at
31357
GO:0000110
GO:0000715
GO:0003677
GO:0003684
GO:0005634
GO:0006281
GO:0006284
GO:0006289
GO:0033683
GO:0043226
GO:0046872
GO:0070914
GO:1901255
Participates
as a component of
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
as an input of
Recruitment of XPA and release of CAK (Drosophila melanogaster)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_476866.1
ENSEMBL
FBpp0070638
,
FBtr0070670
PRO
P28518
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34082
2
Fas2 [extracellular region]
(R-DME-8941043)
Fas2 [plasma membrane]
(R-DME-8940745)
0.527
2
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