Reactome | IntS4 [nucleoplasm]

IntS4 [nucleoplasm]

Stable Identifier

R-DME-6807462

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

INTS4, Q9W3E1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
    - Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Drosophila melanogaster)
      - Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Drosophila melanogaster)
        
        Integrator [nucleoplasm] (Drosophila melanogaster)
        
        IntS4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W3E1

Gene Names

IntS4

Reference Genes

BioGPS Gene:31793 IntS4

ENSEMBL:FBgn0026679

Flybase:FBgn0026679

KEGG Gene (Drosophila melanogaster):Dmel_CG12113 IntS4

Monarch:31793 IntS4

NCBI Gene:31793 IntS4

UCSC:Q9W3E1 IntS4

Reference Transcript

RefSeq:NM_132260.3 IntS4

Other Identifiers

152496_at

1629198_at

31793

GO:0003674

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Drosophila melanogaster)

Inferred From

INTS4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_572488.1

Flybase

FBgn0026679

PRO

Q9W3E1

PDB

7SN8

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9VH81	2	PpD3 [nucleoplasm] (R-DME-5683410) PpD3 [cytosol] (R-DME-5675402)	0.462	2