Reactome | Orc4 [nucleoplasm]

Orc4 [nucleoplasm]

Stable Identifier

R-DME-68519

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ORC4, Q9W102

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle Checkpoints (Drosophila melanogaster)
  - G2/M Checkpoints (Drosophila melanogaster)
    - Activation of ATR in response to replication stress (Drosophila melanogaster)
      - Activation of claspin (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - Loading of claspin onto DNA during replication origin firing (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
- Cell Cycle, Mitotic (Drosophila melanogaster)
  - Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
    - G1/S Transition (Drosophila melanogaster)
      - Activation of the pre-replicative complex (Drosophila melanogaster)
        
        Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        Cdt1 is displaced from the pre-replicative complex (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)
        
        MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Synthesis of DNA (Drosophila melanogaster)
      - Switching of origins to a post-replicative state (Drosophila melanogaster)
        
        Orc1 removal from chromatin (Drosophila melanogaster)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)

DNA Replication (Drosophila melanogaster)

- DNA Replication Pre-Initiation (Drosophila melanogaster)
  - Activation of the pre-replicative complex (Drosophila melanogaster)
    - Cdc45 associates with the pre-replicative complex at the origin (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - Cdt1 is displaced from the pre-replicative complex (Drosophila melanogaster)
      - MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - DNA polymerase alpha:primase binds at the origin (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - DNA polymerase epsilon binds at the origin (Drosophila melanogaster)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Drosophila melanogaster)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        active pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Drosophila melanogaster)
      - MCM10:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
  - Assembly of the pre-replicative complex (Drosophila melanogaster)
    - Assembly of the ORC complex at the origin of replication (Drosophila melanogaster)
      - Formation of ORC(1-5) complex (Drosophila melanogaster)
        
        ORC(1-5):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5) [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - Formation of ORC(1-6) complex (Drosophila melanogaster)
        
        ORC(1-5):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5) [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-6):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5) [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
      - Formation of ORC(2-5) complex (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
    - CDC6 association with the ORC:origin complex (Drosophila melanogaster)
      - CDC6 association with ORC(1-6) at replication origins (Drosophila melanogaster)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-6):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5) [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-6):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5):origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        ORC(1-5) [nucleoplasm] (Drosophila melanogaster)
        
        ORC(2-5) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
- Synthesis of DNA (Drosophila melanogaster)
  - Switching of origins to a post-replicative state (Drosophila melanogaster)
    - Orc1 removal from chromatin (Drosophila melanogaster)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)
        
        pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        CDC6:ORC:origin complex [nucleoplasm] (Drosophila melanogaster)
        
        ORC:origin of replication [nucleoplasm] (Drosophila melanogaster)
        
        Orc4 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W102

Gene Names

Orc4

Reference Genes

BioGPS Gene:37970 Orc4

ENSEMBL:FBgn0023181

FlyBase:FBgn0023181

KEGG:dme:Dmel_CG2917 Orc4

Monarch:37970 Orc4

NCBI Gene:37970 Orc4

UCSC:Q9W102 Orc4

Reference Transcript

RefSeq:NM_057972.4 Orc4

Other Identifiers

142883_at

1639877_at

37970

GO:0000808

GO:0003677

GO:0003688

GO:0003824

GO:0005515

GO:0005634

GO:0005643

GO:0005664

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0043021

GO:0043226

Participates

as a component of

as an input of

Formation of ORC(2-5) complex (Drosophila melanogaster)

Inferred From

ORC4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_477320.1

ENSEMBL

FBtr0072425, FBpp0072330, FBgn0023181

FlyBase

FBgn0023181

PDB

7JK2, 4XGC, 7JK3, 7JK5, 7JGS, 7JGR, 7JK4, 7JK6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O16810	5	phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-DME-9032195) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-DME-9032189) phospho-p-S,T-ORC1 [nucleoplasm] (R-DME-68943) ORC1 [cytosol] (R-DME-113840) ORC1 [nucleoplasm] (R-DME-68522)	0.61	9

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