Reactome | RpS16 [cytosol]

RpS16 [cytosol]

Stable Identifier

R-DME-72337

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPS16, Q9W237

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS16 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS16 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS16 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS16 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS16 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W237

Gene Names

RpS16

Reference Genes

BioGPS Gene:37580 RpS16

ENSEMBL:FBgn0034743

FlyBase:FBgn0034743

KEGG:dme:Dmel_CG4046 RpS16

Monarch:37580 RpS16

NCBI Gene:37580 RpS16

UCSC:Q9W237 RpS16

Reference Transcript

Other Identifiers

147686_at

1639270_at

37580

GO:0000462

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0022626

GO:0022627

GO:1990904

Participates

as a component of

Other forms of this molecule

RpS16 [nucleoplasm]

Inferred From

RPS16 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001286731.1, NP_611685.1

ENSEMBL

FBtr0071855, FBpp0309759, FBpp0071766, FBgn0034743, FBtr0343002

FlyBase

FBgn0034743

PRO

Q9W237

PDB

6XU7, 6XU8, 4V6W, 6XU6

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q0E8S4 Q0E8S4			0.462	2
UniProt:M9NFI9 M9NFI9			0.462	2
UniProt:P18431-3 SGG			0.462	2
UniProt:Q9VVX3 fz2	4	fz2 [clathrin-coated endocytic vesicle membrane] (R-DME-5140725) fz2 [plasma membrane] (R-DME-443947) FZ2 [plasma membrane] (R-DME-205768) fz2 [plasma membrane] (R-DME-443952)	0.462	2

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