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phospho-Shc [cytosol]
Stable Identifier
R-DME-74684
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-Y427-SHC1, Q9V3C8
Locations in the PathwayBrowser
Expand all
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Platelet Aggregation (Plug Formation) (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Integrin signaling (Drosophila melanogaster)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
Signal attenuation (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
phospho-Shc [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3C8
Gene Names
Shc
Reference Genes
BioGPS Gene:44052 Shc
CTD Gene:44052 Shc
ENSEMBL:FBgn0015296
FlyBase:FBgn0015296
KEGG:dme:Dmel_CG3715 Shc
Monarch:44052 Shc
NCBI Gene:44052 Shc
UCSC:Q9V3C8 Shc
Reference Transcript
RefSeq:NM_079944.3 Shc
Other Identifiers
143792_at
1623967_at
44052
GO:0001751
GO:0002376
GO:0005154
GO:0005886
GO:0007163
GO:0007169
GO:0007173
GO:0007298
GO:0007362
GO:0007426
GO:0007427
GO:0007474
GO:0008069
GO:0008078
GO:0008293
GO:0008543
GO:0019901
GO:0022414
GO:0030154
GO:0030971
GO:0035011
GO:0035556
GO:0048010
GO:0048870
GO:0051179
GO:0098542
GO:1904263
GO:1905815
Participates
as an output of
SHC1 dissociates from integrin alphaIIb beta3 (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates (Drosophila melanogaster)
as a component of
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Drosophila melanogaster)
GRB2-1:p-4S-SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Drosophila melanogaster)
as an input of
GRB2-1:SOS1 binds p-Y427-SHC1 (Drosophila melanogaster)
Other forms of this molecule
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [plasma membrane]
phospho-Shc [plasma membrane]
phospho-Shc [cytosol]
Shc [cytosol]
Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
phospho-Shc [cytosol]
Inferred From
p-Y427-SHC1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 427 (in Homo sapiens)
Coordinate
427
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_524683.2
ENSEMBL
FBtr0076458
,
FBpp0076186
,
FBgn0015296
FlyBase
FBgn0015296
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VQ77 Q9VQ77
0.488
2
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