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PI3K [cytosol]
Stable Identifier
R-DME-74693
Type
Complex
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL ubiquitinates PI3K (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PIK3C(1) [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)
PIK3(2) [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS:GTP binds PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K alpha, gamma [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
PI3K alpha, gamma [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
Active ALK:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
PI3-kinase binds to the active receptor (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Pi3K21B [cytosol]
(Drosophila melanogaster)
Pi3K92E [cytosol]
(Drosophila melanogaster)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PIK3C(1) [cytosol] (Drosophila melanogaster)
PIK3(2) [cytosol] (Drosophila melanogaster)
as a component of
Active ALK:PI3K [plasma membrane] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:PI3K [plasma membrane] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Drosophila melanogaster)
as an input of
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
RAS:GTP binds PI3K (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
PI3-kinase binds to the active receptor (Drosophila melanogaster)
Inferred From
PI3K alpha, beta, gamma [cytosol]
(Homo sapiens)
PIK3CB:PIK3R1 [cytosol]
(Homo sapiens)
PI3K beta [cytosol]
(Homo sapiens)
PI3K [cytosol]
(Homo sapiens)
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