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Pi3K92E [cytosol]
Stable Identifier
R-DME-74788
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
PIK3CB, P91634
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
RET signaling (Drosophila melanogaster)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Drosophila melanogaster)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL ubiquitinates PI3K (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
K63polyUb-PI3K beta [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Drosophila melanogaster)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p85-containing Class 1A PI3Ks [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
Role of LAT2/NTAL/LAB on calcium mobilization (Drosophila melanogaster)
PI3K associates with phosphorylated GAB2 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Phosphorylation of PIP2 to PIP3 by PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Phospholipid metabolism (Drosophila melanogaster)
PI Metabolism (Drosophila melanogaster)
Synthesis of PIPs at the plasma membrane (Drosophila melanogaster)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Drosophila melanogaster)
PIK3C(1) [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R2 [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R3 [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Drosophila melanogaster)
PIK3(2) [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R2 [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R3 [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS:GTP binds PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p21 RAS:GTP:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Drosophila melanogaster)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K alpha, gamma [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PI3K alpha, gamma [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ALK (Drosophila melanogaster)
PI3K synthesizes PIP3 downstream of ALK (Drosophila melanogaster)
Active ALK:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
Downstream signal transduction (Drosophila melanogaster)
PI3-kinase binds to the active receptor (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Drosophila melanogaster)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Pi3K92E [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P91634 Pi3K92E
Gene Names
Pi3K92E, CG4141, Dmel_CG4141
Reference Genes
BioGPS Gene:42446 Pi3K92E
CTD Gene:42446 Pi3K92E
KEGG:dme:Dmel_CG4141 Pi3K92E
Monarch:42446 Pi3K92E
NCBI Gene:42446 Pi3K92E
UCSC:P91634 Pi3K92E
Reference Transcript
RefSeq:NM_142645.3 Pi3K92E
RefSeq:NM_001275841.1 Pi3K92E
RefSeq:NM_169910.2 Pi3K92E
Other Identifiers
143789_at
1631594_s_at
42446
GO:0002164
GO:0002168
GO:0003824
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0005942
GO:0005943
GO:0006629
GO:0006914
GO:0006979
GO:0007346
GO:0007552
GO:0008286
GO:0008361
GO:0009267
GO:0010507
GO:0010884
GO:0014065
GO:0016020
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0022414
GO:0030307
GO:0030536
GO:0030707
GO:0033500
GO:0034330
GO:0035004
GO:0035005
GO:0035099
GO:0035205
GO:0035212
GO:0035264
GO:0036092
GO:0036099
GO:0036335
GO:0040014
GO:0042127
GO:0042593
GO:0042691
GO:0043491
GO:0045572
GO:0045615
GO:0045727
GO:0045793
GO:0045887
GO:0046622
GO:0046854
GO:0046934
GO:0048010
GO:0048015
GO:0048167
GO:0048169
GO:0048477
GO:0048542
GO:0048813
GO:0048856
GO:0048870
GO:0050773
GO:0051823
GO:0051897
GO:0052742
GO:0052812
GO:0055088
GO:0055115
GO:0060074
GO:0071902
GO:1903688
GO:1904801
GO:2000252
GO:2000377
Participates
as a component of
K63polyUb-PI3K beta [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R2 [cytosol] (Drosophila melanogaster)
PIK3CB:PIK3R3 [cytosol] (Drosophila melanogaster)
PI3K [cytosol] (Drosophila melanogaster)
Other forms of this molecule
PI3K92E [cytosol]
Pi3K92E [cytosol]
Pi3K92E [cytosol]
Pi3K92E [plasma membrane]
Inferred From
PI3K-catalytic subunit [cytosol]
(Homo sapiens)
PIK3CB [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_650902.1
,
NP_001262770.1
,
NP_732536.1
ENSEMBL
FBpp0306705
,
FBtr0083940
,
FBtr0083941
,
FBtr0334643
,
FBpp0083349
,
FBpp0083348
,
FBgn0015279
FlyBase
FBgn0015279
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