Reactome | Dmel\CG8176 [cytosol]

Dmel\CG8176 [cytosol]

Stable Identifier

R-DME-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

FCHO1, Q6AWD5

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
        
        FCHO1,2 dimer [cytosol] (Drosophila melanogaster)
        
        FCHO1 dimer [cytosol] (Drosophila melanogaster)
        
        Dmel\CG8176 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q6AWD5

Gene Names

Dmel\CG8176

Reference Genes

BioGPS Gene:261329 Dmel\CG8176

ENSEMBL:FBgn0037702

Flybase:FBgn0037702

KEGG Gene (Drosophila melanogaster):Dmel_CG8176 Dmel\CG8176

Monarch:261329 Dmel\CG8176

NCBI Gene:261329 Dmel\CG8176

UCSC:Q6AWD5 Dmel\CG8176

Reference Transcript

Other Identifiers

154688_at

1630227_a_at

261329

GO:0005543

GO:0005737

GO:0005886

GO:0005905

GO:0008289

GO:0016192

GO:0030136

GO:0031410

GO:0035612

GO:0043226

GO:0048268

GO:0065003

GO:0072583

Participates

as a component of

FCHO1 dimer [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Dmel\CG8176 [cytosol]

Inferred From

FCHO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001097723.1, NP_001097724.2

Flybase

FBgn0037702

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