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Cftr [plasma membrane]
Stable Identifier
R-DME-8867595-7
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
PolyUb-CFTR, Q9VC63
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 cargo [plasma membrane] (Drosophila melanogaster)
AP-2 YXXPhi cargo [plasma membrane] (Drosophila melanogaster)
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Cftr [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VC63
Gene Names
Cftr
Reference Genes
BioGPS Gene:42928 Cftr
ENSEMBL:FBgn0039207
FlyBase:FBgn0039207
KEGG:dme:Dmel_CG5789 Cftr
Monarch:42928 Cftr
NCBI Gene:42928 Cftr
UCSC:Q9VC63 Cftr
Reference Transcript
RefSeq:NM_001260357.1 Cftr
RefSeq:NM_143012.3 Cftr
Other Identifiers
154494_at
1632273_at
42928
GO:0003824
GO:0005215
GO:0005524
GO:0016020
GO:0016787
GO:0016887
GO:0042626
GO:0055085
GO:0140359
GO:0140657
Participates
as a member of
Homologues of PolyUb-CFTR [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
Cftr [clathrin-coated endocytic vesicle membrane]
Cftr [plasma membrane]
Cftr [endoplasmic reticulum membrane]
Inferred From
PolyUb-CFTR [plasma membrane]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [cytosol]) at unknown position
Modification
PolyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_651269.1
,
NP_001247286.1
ENSEMBL
FBtr0089906
,
FBtr0306025
,
FBpp0088845
,
FBgn0039207
,
FBpp0297167
FlyBase
FBgn0039207
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