Reactome | rgn [clathrin-coated endocytic vesicle membrane]

rgn [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DME-8869127

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

TGOLN2, M9PFV8

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
    - RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        rgn [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:M9PFV8

Gene Names

rgn

Reference Genes

BioGPS Gene:40368 rgn

ENSEMBL:FBgn0261258

FlyBase:FBgn0261258

KEGG:dme:Dmel_CG6014 rgn

Monarch:40368 rgn

NCBI Gene:40368 rgn

UCSC:M9PFV8 rgn

Reference Transcript

Other Identifiers

152405_at

1635199_at

40368

GO:0003824

GO:0003906

GO:0005634

GO:0005768

GO:0005802

GO:0006281

GO:0006284

GO:0016787

GO:0019104

GO:0030140

GO:0030246

GO:0031410

GO:0042246

GO:0043226

GO:0048856

GO:0140097

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Other forms of this molecule

rgn [plasma membrane]

rgn [Golgi membrane]

rgn [cytoplasmic vesicle membrane]

rgn [trans-Golgi network membrane]

phospho-rgn [endoplasmic reticulum lumen]

rgn [endoplasmic reticulum lumen]

Inferred From

TGOLN2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

ENSEMBL

FBpp0301169, FBgn0261258, FBtr0309230, FBpp0305577, FBtr0333385

FlyBase

FBgn0261258

Cite Us!