Reactome | ATP6V1A [cytosol]

ATP6V1A [cytosol]

Stable Identifier

R-DME-912602

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

Q27331

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to starvation (Drosophila melanogaster)
    - Amino acids regulate mTORC1 (Drosophila melanogaster)
      - RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - RRAGC,D hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - mTORC1 binds RHEB:GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by Insulin receptor (Drosophila melanogaster)
    - Insulin receptor recycling (Drosophila melanogaster)
      - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - Endosome acidification (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)

Transport of small molecules (Drosophila melanogaster)

- Ion channel transport (Drosophila melanogaster)
  - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
    - V-ATPase [endosome membrane] (Drosophila melanogaster)
      - ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
    - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
      - V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
- Iron uptake and transport (Drosophila melanogaster)
  - Transferrin endocytosis and recycling (Drosophila melanogaster)
    - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
      - V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
      - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)
    - Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
      - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1A trimer [cytosol] (Drosophila melanogaster)
        
        ATP6V1A [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q27331

Reference Genes

BioGPS Gene:45012

ENSEMBL:FBgn0263598

Flybase:FBgn0263598

KEGG Gene (Drosophila melanogaster):Dmel_CG3762

Monarch:45012

NCBI Gene:45012

UCSC:Q27331

Reference Transcript

Other Identifiers

146305_at

1634961_s_at

45012

GO:0000166

GO:0000221

GO:0003824

GO:0005215

GO:0005524

GO:0005773

GO:0005886

GO:0006811

GO:0007446

GO:0015986

GO:0016192

GO:0016197

GO:0016787

GO:0016874

GO:0016887

GO:0033180

GO:0033181

GO:0035149

GO:0043226

GO:0046034

GO:0046933

GO:0046961

GO:0048388

GO:0048856

GO:0055085

GO:0055086

GO:0140657

GO:1901135

GO:1902600

Participates

as a component of

ATP6V1A trimer [cytosol] (Drosophila melanogaster)

Inferred From

ATP6V1A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_723775.1, NP_001260425.1, NP_723776.1, NP_001260424.1, NP_001246015.1, NP_652004.2

Flybase

FBgn0263598

PRO

Q27331

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