Reactome | C3G [cytosol]

C3G [cytosol]

Stable Identifier

R-DME-913472

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RAPGEF1, O77086

Locations in the PathwayBrowser

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Signal Transduction (Drosophila melanogaster)

- Signaling by Erythropoietin (Drosophila melanogaster)
  - Erythropoietin activates RAS (Drosophila melanogaster)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Drosophila melanogaster)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Drosophila melanogaster)
        
        p-CRKL:RAPGEF1 [cytosol] (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Drosophila melanogaster)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Drosophila melanogaster)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Drosophila melanogaster)
        
        p-CRKL:RAPGEF1 [cytosol] (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)
- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by PDGF (Drosophila melanogaster)
    - Downstream signal transduction (Drosophila melanogaster)
      - p130Cas and C3G bind PDGFR bound Crk (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)
        
        PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
  - Signaling by Rho GTPases (Drosophila melanogaster)
    - RHO GTPase cycle (Drosophila melanogaster)
      - RAC3 GTPase cycle (Drosophila melanogaster)
        
        RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)
        
        RAC3 effectors [cytosol] (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)
        
        RAC3:GTP:RAC3 effectors [plasma membrane] (Drosophila melanogaster)
        
        RAC3 effectors [cytosol] (Drosophila melanogaster)
        
        C3G [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O77086

Gene Names

C3G

Reference Genes

BioGPS Gene:31618 C3G

ENSEMBL:FBgn0259228

Flybase:FBgn0259228

KEGG Gene (Drosophila melanogaster):Dmel_CG42328 C3G

Monarch:31618 C3G

NCBI Gene:31618 C3G

UCSC:O77086 C3G

Reference Transcript

Other Identifiers

144121_at

1633115_a_at

31618

GO:0005085

GO:0005575

GO:0005886

GO:0007010

GO:0007264

GO:0007265

GO:0007525

GO:0016203

GO:0017124

GO:0023052

GO:0030154

GO:0043087

GO:0043547

GO:0045214

GO:0045880

GO:0048856

GO:0098772

Participates

as a component of

as a candidate of

RAC3 effectors [cytosol] (Drosophila melanogaster)

as an input of

Inferred From

RAPGEF1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_572350.2, NP_788867.1

Flybase

FBgn0259228

PRO

O77086

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34082	2	Fas2 [extracellular region] (R-DME-8941043) Fas2 [plasma membrane] (R-DME-8940745)	0.527	2