Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-DME-9624425
Type
Complex
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR autophosphorylation (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
Binding of CBL to EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
CBL binds and ubiquitinates phosphorylated Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
CBL ubiquitinates Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGFR interacts with phospholipase C-gamma (Drosophila melanogaster)
Active PLC-gamma1 dissociates from EGFR (Drosophila melanogaster)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGFR activates PLC-gamma1 by phosphorylation (Drosophila melanogaster)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
GAB1 signalosome (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SHP2 dephosphorylates Tyr 992 on EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Sustained activation of SRC kinase by SHP2 (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
GRB2 events in EGFR signaling (Drosophila melanogaster)
GRB2:SOS1 complex binds to EGF:EGFR complex (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
Phosphorylation of EGFR by SRC kinase (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SHC1 events in EGFR signaling (Drosophila melanogaster)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SHC1 phosphorylation by phosphorylated EGFR (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Homologues of EGF [extracellular region]
(Drosophila melanogaster)
x 2
phospho-p-6Y-EGFR [plasma membrane]
(Drosophila melanogaster)
Participates
as an input of
Localization of CBL:GRB2 to the membrane (Drosophila melanogaster)
Binding of CBL to EGFR (Drosophila melanogaster)
GRB2:SOS1 complex binds to EGF:EGFR complex (Drosophila melanogaster)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Drosophila melanogaster)
Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)
GRB2:GAB1 binds to phosphorylated EGFR (Drosophila melanogaster)
as a component of
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Drosophila melanogaster)
as an output of
Active PLC-gamma1 dissociates from EGFR (Drosophila melanogaster)
Phosphorylation of EGFR by SRC kinase (Drosophila melanogaster)
EGFR autophosphorylation (Drosophila melanogaster)
Inferred From
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Homo sapiens)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text