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Lis-1 [cytosol]
Stable Identifier
R-DME-976035
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
FBXW11, Q7KNS3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Downstream signaling events of B Cell Receptor (BCR) (Drosophila melanogaster)
Activation of NF-kappaB in B cells (Drosophila melanogaster)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
SCF-beta-TrCP ubiquitinylates IkB (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Downstream TCR signaling (Drosophila melanogaster)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
TNFR2 non-canonical NF-kB pathway (Drosophila melanogaster)
NIK-->noncanonical NF-kB signaling (Drosophila melanogaster)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
Dectin-1 mediated noncanonical NF-kB signaling (Drosophila melanogaster)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Drosophila melanogaster)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated NF-kB activation (Drosophila melanogaster)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Drosophila melanogaster)
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL1 E3 ligase complex [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
SCF E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Drosophila melanogaster)
Lis-1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7KNS3
Gene Names
Lis-1
Reference Genes
BioGPS Gene:36791 Lis-1
CTD Gene:36791 Lis-1
ENSEMBL:FBgn0015754
Flybase:FBgn0015754
KEGG Gene (Drosophila melanogaster):Dmel_CG8440 Lis-1
Monarch:36791 Lis-1
NCBI Gene:36791 Lis-1
UCSC:Q7KNS3 Lis-1
Reference Transcript
RefSeq:NM_057812.5 Lis-1
RefSeq:NM_001259432.2 Lis-1
RefSeq:NM_206130.2 Lis-1
RefSeq:NM_176190.2 Lis-1
Other Identifiers
143837_at
1624854_s_at
36791
GO:0000132
GO:0000278
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005635
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005828
GO:0005829
GO:0005856
GO:0005869
GO:0005874
GO:0005875
GO:0005881
GO:0005938
GO:0006886
GO:0007010
GO:0007017
GO:0007018
GO:0007049
GO:0007059
GO:0007097
GO:0007163
GO:0007281
GO:0007283
GO:0007294
GO:0007298
GO:0007303
GO:0007312
GO:0007399
GO:0007405
GO:0008088
GO:0008090
GO:0008092
GO:0008104
GO:0008298
GO:0010970
GO:0016192
GO:0016319
GO:0016358
GO:0019827
GO:0022414
GO:0023052
GO:0030154
GO:0030286
GO:0030381
GO:0030424
GO:0030425
GO:0030426
GO:0030473
GO:0030513
GO:0030706
GO:0030716
GO:0030723
GO:0031023
GO:0031616
GO:0034501
GO:0042052
GO:0043005
GO:0043025
GO:0043226
GO:0045478
GO:0045842
GO:0046716
GO:0047496
GO:0048135
GO:0048142
GO:0048477
GO:0048813
GO:0048814
GO:0048854
GO:0048856
GO:0048870
GO:0050772
GO:0051010
GO:0051012
GO:0051225
GO:0051299
GO:0051301
GO:0051383
GO:0051642
GO:0051647
GO:0061883
GO:0070840
GO:0072499
GO:0098930
GO:0140014
GO:1904115
Participates
as a member of
F-box protein [cytosol] (Drosophila melanogaster)
as a component of
CUL1:FBXW11:SKP1 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Lis-1 [cytosol]
Inferred From
beta-TrCP [cytosol]
(Homo sapiens)
FBXW11 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_788370.1
,
NP_995852.1
,
NP_477160.1
,
NP_001246361.1
Flybase
FBgn0015754
PRO
Q7KNS3
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