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phospho-p-Y187,Y198-CHUK [cytosol]
Stable Identifier
R-DME-9861501
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q9VEZ5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to mechanical stimuli (Drosophila melanogaster)
Response of endothelial cells to shear stress (Drosophila melanogaster)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Drosophila melanogaster)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Drosophila melanogaster)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
phospho-p-Y187,Y198-CHUK [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VEZ5 IKKbeta
Gene Names
IKKbeta, DIK, ird5, CG4201
Chain
chain:1-751
Reference Genes
BioGPS Gene:44432 IKKbeta
KEGG:dme:Dmel_CG4201 IKKbeta
Monarch:44432 IKKbeta
NCBI Gene:44432 IKKbeta
UCSC:Q9VEZ5 IKKbeta
Reference Transcript
RefSeq:NM_080012.4 IKKbeta
Other Identifiers
142654_at
1625974_at
44432
GO:0002230
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006355
GO:0006468
GO:0006963
GO:0008384
GO:0008385
GO:0016740
GO:0019731
GO:0030163
GO:0033209
GO:0042802
GO:0043123
GO:0045087
GO:0045088
GO:0045944
GO:0051607
GO:0061057
GO:0071456
GO:0098542
GO:0140096
GO:0140896
Participates
as a component of
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Drosophila melanogaster)
Other forms of this molecule
IRD5 [cytosol]
Phospho IRD5 [cytosol]
phospho-p-T23-CHUK [cytosol]
phospho-p-S176,S180-CHUK [cytosol]
phospho-p-S177,S181-IKBKB [cytosol]
CHUK [cytosol]
IKBKB [cytosol]
Inferred From
p-Y187,Y198-CHUK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 198 (in Homo sapiens)
Coordinate
198
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_524751.3
ENSEMBL
FBtr0304804
,
FBpp0293344
FlyBase
FBgn0024222
PRO
Q9VEZ5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GYV5 key
10
KEY [cytosol]
(R-DME-206178)
OPTN [recycling endosome membrane]
(R-DME-8854141)
IKBKG [nucleoplasm]
(R-DME-4755413)
OPTN [Golgi membrane]
(R-DME-2161111)
phospho-p-S177-OPTN [nucleoplasm]
(R-DME-2562595)
phospho-p-S177-OPTN [cytosol]
(R-DME-2562525)
K63polyUb-IKBKG [cytosol]
(R-DME-202530)
IKBKG [cytosol]
(R-DME-168108)
OPTN [cytosol]
(R-DME-9687907)
phospho-p-S177,S473,S513-OPTN [cytosol]
(R-DME-9687840)
0.632
4
UniProt:Q9VEZ5 IKKbeta
8
IRD5 [cytosol]
(R-DME-206001)
Phospho IRD5 [cytosol]
(R-DME-206139)
phospho-p-Y187,Y198-CHUK [cytosol]
(R-DME-9861501)
phospho-p-T23-CHUK [cytosol]
(R-DME-198615)
phospho-p-S176,S180-CHUK [cytosol]
(R-DME-177667)
phospho-p-S177,S181-IKBKB [cytosol]
(R-DME-202506)
CHUK [cytosol]
(R-DME-168104)
IKBKB [cytosol]
(R-DME-168114)
0.623
2
UniProt:Q03017 cact
6
CACT [cytosol]
(R-DME-205871)
Phospho CACT [cytosol]
(R-DME-205886)
cact [nucleoplasm]
(R-DME-4656929)
phospho-cact [cytosol]
(R-DME-1168581)
phospho-cact [cytosol]
(R-DME-177677)
cact [cytosol]
(R-DME-168151)
0.544
2
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