Reactome | rbm8a [cytosol]

rbm8a [cytosol]

Stable Identifier

R-DRE-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RBM8A, Q5D018

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - Transport of Mature Transcript to Cytoplasm (Danio rerio)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Danio rerio)
      - Transport of the export-competent mRNP complex through the NPC (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
      - mRNP complex dissociates from cytosolic face of NPC (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        rbm8a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5D018

Gene Names

rbm8a

Reference Genes

BioGPS Gene:503767 rbm8a

ENSEMBL:ENSDARG00000016516

KEGG Gene (Danio rerio):503767 rbm8a

Monarch:503767 rbm8a

NCBI Gene:503767 rbm8a

Reference Transcript

RefSeq:NM_001013345.1 rbm8a

Other Identifiers

13034589

503767

A_15_P142491

A_15_P506952

A_15_P740361

DRER02260

Dr.4412.15.S1_at

ENSDART00000018253

ENSDART00000018253_1

ENSDART00000018253_2

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005737

GO:0006396

GO:0043226

GT_Spec_NM_001013345.1_302225

MADDr01001058

NM_001013345

TC238169

ZV700S00005315

Participates

as a component of

Magoh-Y14 complex [cytosol] (Danio rerio)

Other forms of this molecule

rbm8a [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001013363.1

ZFIN

ZDB-GENE-050306-51

Ensembl

ENSDART00000018253, ENSDARG00000016516, ENSDARP00000026575

PRO

Q5D018

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