Reactome | ube2e2 [nucleoplasm]

ube2e2 [nucleoplasm]

Stable Identifier

R-DRE-174063

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

UBE2E1, Q6DG68

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        Phosphorylation of the APC/C (Danio rerio)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Free APC/C phosphorylated by Plk1 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Danio rerio)
        
        Degradation of multiubiquitinated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular Senescence (Danio rerio)
    - Senescence-Associated Secretory Phenotype (SASP) (Danio rerio)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2e2 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DG68

Gene Names

ube2e2

Reference Genes

BioGPS Gene:445100 ube2e2

ENSEMBL:ENSDARG00000034670

KEGG Gene (Danio rerio):445100 ube2e2

Monarch:445100 ube2e2

NCBI Gene:445100 ube2e2

Reference Transcript

RefSeq:NM_001003494.1 ube2e2

Other Identifiers

13034920

445100

A_15_P105818

A_15_P121194

A_15_P196661

A_15_P412420

DRER06018

DRER55032

Dr.4810.1.A1_at

ENSDART00000014041

ENSDART00000014041_1

ENSDART00000014041_2

ENSDART00000049375

GO:0000166

GO:0000209

GO:0003674

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0006464

GO:0008150

GO:0016740

GO:0043167

GO:0043226

GO:0061631

GO:0070936

GT_Spec_NM_001003494.1_187635

LOLS02992

MADDr01000569

NM_001003494

TC243678

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Danio rerio)

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)

Other forms of this molecule

ube2e2 [nucleoplasm]

ube2e2 [cytosol]

Inferred From

UBE2E1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001003494.1

Ensembl

ENSDARP00000049374, ENSDARG00000034670, ENSDART00000049375

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