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FGF23(25-251) [extracellular region]
Stable Identifier
R-DRE-189891
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
extracellular region
Synonyms
Q5MK87
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
Activated FGFR1 binds FLRT1,2,3 (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:FLRT [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
FRS-mediated FGFR1 signaling (Danio rerio)
Activated FGFR1 binds FRS3 (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1 phosphorylates FRS2 (Danio rerio)
Activated FGFR1:FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1 phosphorylates FRS3 (Danio rerio)
Activated FGFR1:FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Danio rerio)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-FRS3 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Phospholipase C-mediated cascade: FGFR1 (Danio rerio)
Activated FGFR1 binds PLCG1 (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
activated FGFR1:PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1 phosphorylates PLCG1 (Danio rerio)
activated FGFR1:PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
p-4Y-PLCG1 dissociates from activated FGFR1 (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
SHC-mediated cascade:FGFR1 (Danio rerio)
Activated FGFR1 phosphorylates SHC1 (Danio rerio)
Activated FGFR1:SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
Activated FGFR1:p-SHC1 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
FGFR1 ligand binding and activation (Danio rerio)
FGFR1c and Klotho ligand binding and activation (Danio rerio)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
FGFR1c binds to Klotho-bound FGF23 (Danio rerio)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Danio rerio)
Activated FGFR1:FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Danio rerio)
Activated FGFR1 [plasma membrane] (Danio rerio)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Danio rerio)
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
FGF23(25-251) [extracellular region] (Danio rerio)
External Reference Information
External Reference
UniProt:Q5MK87
Reference Genes
BioGPS Gene:494456
ENSEMBL:ENSDARG00000045854
KEGG Gene (Danio rerio):494456
Monarch:494456
NCBI Gene:494456
Reference Transcript
RefSeq:NM_001009564.2
Participates
as a component of
Klotho bound to FGF23 [plasma membrane] (Danio rerio)
Other forms of this molecule
FGF23(25-251) [Golgi lumen]
GalNAc-T178-FGF23(25-251) [Golgi lumen]
GalNAc-T178-FGF23(25-251) [extracellular region]
Inferred From
FGF23(25-251) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001009564.2
ZFIN
ZDB-GENE-050201-4
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