Reactome | arpc4 [cytosol]

arpc4 [cytosol]

Stable Identifier

R-DRE-200813

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ARPC4, Q6NZZ2

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - EPH-Ephrin signaling (Danio rerio)
      - EPHB-mediated forward signaling (Danio rerio)
        
        N-WASP binds ARP2/3 and G-actin (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Innate Immune System (Danio rerio)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
    - Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
      - Branching and elongation of mother and daughter filaments (Danio rerio)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Mother filament:branching complex:daughter filament [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
      - Detachment of WASP/WAVE (Danio rerio)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases Activate WASPs and WAVEs (Danio rerio)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Branching and elongation of mother and daughter filaments (Danio rerio)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Mother filament:branching complex:daughter filament [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Detachment of WASP/WAVE (Danio rerio)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)
        
        arpc4 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6NZZ2

Gene Names

arpc4

Reference Genes

BioGPS Gene:114456 arpc4

BioGPS Gene:445305 arpc4

CTD Gene:445305 arpc4

ENSEMBL:ENSDARG00000054063

KEGG:dre:114456 arpc4

KEGG:dre:445305 arpc4

Monarch:114456 arpc4

Monarch:445305 arpc4

NCBI Gene:114456 arpc4

NCBI Gene:445305 arpc4

UCSC:Q6NZZ2 arpc4

Reference Transcript

Other Identifiers

114456

12978839

13222644

445305

A_15_P102017

A_15_P118217

A_15_P176656

A_15_P271726

A_15_P546472

A_15_P723206

A_15_P724676

CJ012556

CJ012630

CUST_1059_PI428451958

CUST_23278_PI428451953

CUST_329_PI428451953

CUST_498_PI428451958

DRER02491

DRER11869

DRER25362

DRER42436

DRER44771

Dr.13393.1.S1_at

Dr.5314.1.S1_at

ENSDART00000019845

ENSDART00000019845_1

ENSDART00000019845_2

ENSDART00000081062

ENSDART00000081062_1

ENSDART00000081062_2

GO:0003779

GO:0005737

GO:0005856

GO:0005885

GO:0008092

GO:0015629

GO:0030041

GO:0034314

GO:0042995

GO:0043226

GO:0051015

GO:0065003

GT_Spec_NM_205537.1_359875

GT_Xhyb_NM_001003762.1_301905

GT_Xhyb_XM_005155804.1_86281

LOLS02765

MADDr01003683

MADDr01006796

NM_001003762

NM_205537

OTTDART00000024636

TC248375

XM_683730

Participates

as a component of

ARP2/3 complex (ATP bound) [cytosol] (Danio rerio)

Inferred From

ARPC4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_991100.1, NP_001003762.1

ENSEMBL

ENSDARP00000105296, ENSDART00000019845, ENSDARP00000025212, ENSDART00000123665, ENSDART00000081062, ENSDART00000184668, ENSDARP00000155849, ENSDARP00000075505

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