Reactome | nck2a [cytosol]

nck2a [cytosol]

Stable Identifier

R-DRE-204885

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

NCK2, F1R1C3

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - EPH-Ephrin signaling (Danio rerio)
      - Ephrin signaling (Danio rerio)
        
        EFNB:GRB4 binds GIT1 (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        GIT1 binds bPIX (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        PAK binds RAC and bPIX (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        PAKs autophosphorylate (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        PAKs phosphorylate MLC (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        p-EFNB binds GRB4 (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - Downstream signal transduction (Danio rerio)
      - Nck binds to the active PDGF receptor (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
  - Signaling by VEGF (Danio rerio)
    - VEGFA-VEGFR2 Pathway (Danio rerio)
      - CDC42:GTP binds PAK2 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - FYN autophosphorylates (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - FYN phosphorylates PAK2 (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - PAK2 autophorylates (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - PAK2 binds NCK (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds FYN (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds NCK (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - p-Y420-FYN is phosphorylated on S21 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - p38 MAPK activation by VEGFR (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase cycle (Danio rerio)
      - RHOU GTPase cycle (Danio rerio)
        
        RHOU binds effectors at the plasma membrane (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
      - RHOV GTPase cycle (Danio rerio)
        
        RHOV binds effectors at the plasma membrane (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        nck2a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F1R1C3

Gene Names

nck2a

Reference Genes

BioGPS Gene:393972 nck2a

CTD Gene:393972 nck2a

ENSEMBL:ENSDARG00000018206

Monarch:393972 nck2a

NCBI Gene:393972 nck2a

Reference Transcript

RefSeq:XM_009304471.2 nck2a

Other Identifiers

13264388

393972

A_15_P111505

A_15_P283156

A_15_P729826

CUST_10017_PI428451953

DRER16151

Dr.9538.1.S1_at

ENSDART00000025527_1

ENSDART00000025527_2

ENSDART00000102672

GO:0003674

GO:0005515

GT_Spec_NM_200997.1_282395

LOLS02477

MADDr01001181

ZV700S00006633

Participates

as a candidate of

RHOV effectors [cytosol] (Danio rerio)

as a member of

as an input of

p-EFNB binds GRB4 (Danio rerio)

as a component of

EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)

Inferred From

NCK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_009302746.1

Ensembl

ENSDARG00000018206, ENSDART00000102672, ENSDARP00000093447

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