Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
wu:fb16a12 [cytosol]
Stable Identifier
R-DRE-205223
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
PIK3R3, A0A0R4IUJ2
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K beta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K delta [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PIK3C(1) [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
G alpha (q) inhibits PI3K alpha (Danio rerio)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
PI3K binds membrane-associated estrogen receptors (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Direct recruitment of PI3K to p-KIT (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
RAC2 GTPase cycle (Danio rerio)
RAC2 binds effectors at the plasma membrane (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
PI3K-regulatory subunits [cytosol] (Danio rerio)
wu:fb16a12 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A0R4IUJ2
Gene Names
wu:fb16a12
Reference Genes
BioGPS Gene:406311 wu:fb16a12
CTD Gene:406311 wu:fb16a12
ENSEMBL:ENSDARG00000103038
ENSEMBL:ENSDARG00000103038.2 wu:fb16a12
KEGG Gene (Danio rerio):406311 wu:fb16a12
Monarch:406311 wu:fb16a12
NCBI Gene:406311 wu:fb16a12
Reference Transcript
RefSeq:NM_213038.2 wu:fb16a12
RefSeq:NM_001291329.1 wu:fb16a12
Other Identifiers
13078476
406311
A_15_P207341
A_15_P286046
CUST_7198_PI428451953
DRER27399
DRER54122
DRER54949
Dr.58.1.A1_at
ENSDART00000067358_1
ENSDART00000067358_2
GO:0005942
GO:0006629
GO:0008286
GO:0023052
GO:0046854
GO:0046935
GO:0098772
GT_Xhyb_XM_005163656.1_273455
JP011516
JP011529
LOLO1555
LOLO1556
LOLS09366
MADDr01003121
NM_213038
ZV700S00005741
Participates
as a component of
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
PIK3CD:PIK3R3 [cytosol] (Danio rerio)
PIK3CB:PIK3R3 [cytosol] (Danio rerio)
as a candidate of
PI3K-regulatory subunits [cytosol] (Danio rerio)
Other forms of this molecule
wu:fb16a12 [cytosol]
Inferred From
PIK3R3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001278258.1
,
NP_998203.2
ZFIN
ZDB-GENE-040426-1978
Ensembl
ENSDARP00000140757
,
ENSDARP00000130273
,
ENSDARG00000103038
,
ENSDART00000167649
,
ENSDART00000160715
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
