Reactome | col2a1b [endoplasmic reticulum lumen]

col2a1b [endoplasmic reticulum lumen]

Stable Identifier

R-DRE-2173160

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

endoplasmic reticulum lumen

Synonyms

3x4Hyp-5Hyl-COL27A1(42-1860), A0A0H2UKU2

Locations in the PathwayBrowser

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Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides (Danio rerio)
      - COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Collagen chain trimerization (Danio rerio)
      - Association of procollagen type XXVII (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Galactosylation of collagen propeptide hydroxylysines by PLOD3 (Danio rerio)
      - PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2. (Danio rerio)
      - COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Lysyl hydroxylated collagen propeptides dissociate from Lysyl hydroxylases (Danio rerio)
      - Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)
      - Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
      - PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines (Danio rerio)
      - Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        4-Hyp, 5-Hyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Procollagen triple helix formation (Danio rerio)
      - Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
      - Procollagen C-linked trimers [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)
    - Secretion of collagens (Danio rerio)
      - Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagens and tropocollagens [endoplasmic reticulum lumen] (Danio rerio)
        
        Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1b [endoplasmic reticulum lumen] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A0H2UKU2

Gene Names

col2a1b

Reference Genes

ENSEMBL:ENSDARG00000011407

Other Identifiers

12976847

13302566

503730

A_15_P721816

CUST_6_PI428451953

DRER05827

ENSDART00000047844

ENSDART00000047844_1

ENSDART00000047844_2

ENSDART00000091307

GO:0003674

GO:0005198

GO:0005201

LOLS09207

XM_693357

Participates

as a member of

Homologues of 3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)

Other forms of this molecule

col2a1b [endoplasmic reticulum lumen]

col2a1b [extracellular region]

Inferred From

3x4Hyp-5Hyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,5R)-5-hydroxylysine at unknown position

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Cross References

Ensembl

ENSDARP00000139349, ENSDARG00000011407, ENSDART00000159169