Reactome | col2a1a [endoplasmic reticulum lumen]

col2a1a [endoplasmic reticulum lumen]

Stable Identifier

R-DRE-2173277-4

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

endoplasmic reticulum lumen

Synonyms

3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860), Q2LDA1

Locations in the PathwayBrowser

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Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Collagen chain trimerization (Danio rerio)
      - Association of procollagen type XXVII (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Glucosylation of collagen propeptide hydroxylysines (Danio rerio)
      - PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Glucosyl-galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        3,4-Hyp Glu-Gal-Hyl-collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
    - PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates (Danio rerio)
      - Glucosyl-galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        3,4-Hyp Glu-Gal-Hyl-collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
      - PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum membrane] (Danio rerio)
        
        Glucosyl-galactosyl-hydroxylysyl collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        3,4-Hyp Glu-Gal-Hyl-collagen propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Procollagen triple helix formation (Danio rerio)
      - Collagen and procollagen triple helices:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagen and procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
      - Procollagen C-linked trimers [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)
    - Secretion of collagens (Danio rerio)
      - Collagens and tropocollagens:Serpin H1 [endoplasmic reticulum lumen] (Danio rerio)
        
        Collagens and tropocollagens [endoplasmic reticulum lumen] (Danio rerio)
        
        Fibrillar procollagen triple helices [endoplasmic reticulum lumen] (Danio rerio)
        
        C-linked procollagen type XXVII trimer [endoplasmic reticulum lumen] (Danio rerio)
        
        Alpha-1(XXVII) propeptides [endoplasmic reticulum lumen] (Danio rerio)
        
        Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)
        
        col2a1a [endoplasmic reticulum lumen] (Danio rerio)

External Reference Information

External Reference

UniProt:Q2LDA1

Gene Names

col2a1a

Reference Genes

BioGPS Gene:562496 col2a1a

CTD Gene:562496 col2a1a

ENSEMBL:ENSDARG00000069093

KEGG Gene (Danio rerio):562496 col2a1a

Monarch:562496 col2a1a

NCBI Gene:562496 col2a1a

Reference Transcript

RefSeq:NM_131292.1 col2a1a

Other Identifiers

13244992

562496

A_15_P189276

A_15_P474985

A_15_P658791

CUST_3591_PI428451958

DRER13915

DRER15313

DRER58806

Dr.3761.1.S1_at

ENSDART00000074375

ENSDART00000074375_1

ENSDART00000074375_2

ENSDART00000091307

GO:0000902

GO:0001501

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005615

GO:0007411

GO:0008150

GO:0009790

GO:0030154

GO:0030198

GO:0030199

GO:0030312

GO:0030903

GO:0031012

GO:0032991

GO:0040011

GO:0043167

GO:0046872

GO:0048706

GO:0048856

GT_Xhyb_XM_005166861.1_63871

GT_Xhyb_XM_005166862.1_63861

GT_Xhyb_XM_005166863.1_63881

GT_Xhyb_XM_005166864.1_63891

LOLS01022

LOLS03965

LOLT00967

MADDr01014122

NM_131292

OTTDART00000025812

XM_682285

XM_687777

XM_691272

XM_703659

Participates

as a member of

Homologues of 3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Danio rerio)

Other forms of this molecule

col2a1a [endoplasmic reticulum lumen]

col2a1a [extracellular region]

Inferred From

3x4Hyp-3Hyp-GlcGalHyl-COL27A1(42-1860) [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-glucosylgalactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-glucosylgalactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_571367.1

Ensembl

ENSDARP00000091007, ENSDARG00000069093, ENSDART00000100234

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