Reactome | tacr1b [plasma membrane]

tacr1b [plasma membrane]

Stable Identifier

R-DRE-380103

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

TACR1, A0A0R4IDZ1

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - ARBB recruits GPCRs into clathrin-coated pits (Danio rerio)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - ARRB bind GPCRs (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        ARRB-binding GPCRs [plasma membrane] (Danio rerio)
        
        tacr1b [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A0R4IDZ1

Gene Names

tacr1b

Reference Genes

ENSEMBL:ENSDARG00000102900

Other Identifiers

12974046

564017

A_15_P158472

CUST_384_PI428451953

CUST_385_PI428451953

DRER34348

ENSDART00000019979

ENSDART00000019979_1

ENSDART00000019979_2

GO:0000003

GO:0003674

GO:0004930

GO:0004995

GO:0005575

GO:0005886

GO:0005929

GO:0007165

GO:0007186

GO:0007217

GO:0008150

GO:0016020

GO:0016021

GO:0016496

GO:0040011

GO:0043226

GO:0048870

GO:0071314

GO:0097225

GO:1902093

XM_687377

Participates

as a candidate of

ARRB-binding GPCRs [plasma membrane] (Danio rerio)

as an input of

Tachykinin receptor 1 (NK1) binds to substance P (Danio rerio)

as a member of

GPCRs that activate Gq/11 [plasma membrane] (Danio rerio)

as a component of

TACR1:TAC1(58-68) [plasma membrane] (Danio rerio)

Other forms of this molecule

tacr1b [clathrin-coated endocytic vesicle membrane]

Inferred From

TACR1 [plasma membrane] (Homo sapiens)

Cross References

ZFIN

ZDB-GENE-091117-17

Ensembl

ENSDARP00000131307, ENSDARG00000102900, ENSDART00000166965

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