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active PDGF-AA dimer [extracellular region]
Stable Identifier
R-DRE-380761
Type
Complex
Species
Danio rerio
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
Exocytosis of platelet alpha granule contents (Danio rerio)
Platelet alpha granule contents [extracellular region] (Danio rerio)
PDGF dimer [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
Autophosphorylation of PDGF alpha receptors (Danio rerio)
PDGF:PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
PDGF:PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Downstream signal transduction (Danio rerio)
Activated PLC gamma dissociates from the PDGF receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Activation of Src (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Crk binds to the active PDGF receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
GRB2:SOS1 complex binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Nck binds to the active PDGF receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PI3-kinase binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PLC-gamma binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
Phosphorylation of PLCgamma by PDGFR (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
SH2 domain of Src binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
STAT binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF dimer binds two receptors simultaneously (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF:PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGF-AA clevage by Furin (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGFRs bind type I TKI (Danio rerio)
PDGF:PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
PDGF:PDGF receptor dimer [plasma membrane] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
active PDGF-AA dimer [extracellular region] (Danio rerio)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
pdgfab [extracellular region]
(Danio rerio)
Participates
as a member of
PDGF dimer [extracellular region] (Danio rerio)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Danio rerio)
as an output of
PDGF-AA clevage by Furin (Danio rerio)
Inferred From
PDGF A homodimer [extracellular region]
(Homo sapiens)
active PDGF-AA dimer [extracellular region]
(Homo sapiens)
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