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sos1 [cytosol]
Stable Identifier
R-DRE-64847
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
SOS1, A2RRV5
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Interaction of SOS-1 to Tie2 bound Grb2 (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signaling (Danio rerio)
p75 NTR receptor-mediated signalling (Danio rerio)
Cell death signalling via NRAGE, NRIF and NADE (Danio rerio)
NRAGE signals death through JNK (Danio rerio)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Danio rerio)
GEFs [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Danio rerio)
sos1 [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (12/13) signalling events (Danio rerio)
GEFs activate RhoA,B,C (Danio rerio)
GEFs [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
G alpha (q) signalling events (Danio rerio)
Gastrin-CREB signalling pathway via PKC and MAPK (Danio rerio)
EGFR Transactivation by Gastrin (Danio rerio)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
GRB2 events in EGFR signaling (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1 complex binds to EGF:EGFR complex (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SHC1 events in EGFR signaling (Danio rerio)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
GRB2 events in ERBB2 signaling (Danio rerio)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
SHC1 events in ERBB4 signaling (Danio rerio)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
FRS-mediated FGFR1 signaling (Danio rerio)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR1 (Danio rerio)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Downstream signaling of activated FGFR2 (Danio rerio)
FRS-mediated FGFR2 signaling (Danio rerio)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR2:pFRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR2 (Danio rerio)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Downstream signaling of activated FGFR3 (Danio rerio)
FRS-mediated FGFR3 signaling (Danio rerio)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR3:pFRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SHC-mediated cascade:FGFR3 (Danio rerio)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Downstream signaling of activated FGFR4 (Danio rerio)
FRS-mediated FGFR4 signaling (Danio rerio)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Danio rerio)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
MET activates RAS signaling (Danio rerio)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
GRB2:SOS1 complex binds to the active receptor (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Activation of RAS by p-KIT bound SOS1 (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS interacts with p-KIT (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Regulation of KIT signaling (Danio rerio)
Recruitment of CBL to KIT (Danio rerio)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
GRB2:SOS1:p-KIT complex [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
RAC1 GTPase cycle (Danio rerio)
RAC1 GEFs activate RAC1 (Danio rerio)
RAC1 GEFs [cytosol] (Danio rerio)
sos1 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A2RRV5
Gene Names
sos1
Reference Genes
BioGPS Gene:556286 sos1
ENSEMBL:ENSDARG00000100503
KEGG:dre:556286 sos1
Monarch:556286 sos1
NCBI Gene:556286 sos1
UCSC:A2RRV5 sos1
Reference Transcript
RefSeq:NM_001082993.1 sos1
Other Identifiers
12928927
12928929
12928931
12928933
12928947
12928949
12928967
12928969
12928971
12928973
12928975
12976642
556286
A_15_P180293
A_15_P237876
A_15_P470220
A_15_P569777
A_15_P667756
CJ012907
CJ013089
DRER08510
ENSDART00000062264_1
ENSDART00000062269
ENSDART00000085310
ENSDART00000085310_1
ENSDART00000085318
GO:0000786
GO:0003677
GO:0005085
GO:0005198
GO:0007264
GO:0030527
GO:0046982
GO:0098772
LOLS15747
NM_001082993
XM_679050
XM_688845
Participates
as a candidate of
RAC1 GEFs [cytosol] (Danio rerio)
as a member of
GEFs [cytosol] (Danio rerio)
as an input of
Interaction of SOS-1 to Tie2 bound Grb2 (Danio rerio)
GRB2-1 binds SOS1 (Danio rerio)
as a component of
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Danio rerio)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Danio rerio)
GRB2-1:SOS1 [cytosol] (Danio rerio)
Inferred From
SOS1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001076462.1
ENSEMBL
ENSDART00000168295
,
ENSDARP00000134064
ZFIN
ZDB-GENE-070209-128
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