Reactome | zgc:110187 [nucleoplasm]

zgc:110187 [nucleoplasm]

Stable Identifier

R-DRE-65567

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

GTF2F2, Q568N8

Locations in the PathwayBrowser

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Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Transcription of DNA Repair Genes (Danio rerio)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Danio rerio)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Danio rerio)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - RNA Pol II CTD phosphorylation and interaction with CE (Danio rerio)
    - Activation of GT (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Danio rerio)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Phosphorylation (Ser5) of RNA pol II CTD (Danio rerio)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - RNA polymerase II transcribes snRNA genes (Danio rerio)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Integrator complex processes the 3' end of snRNA (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)

Metabolism of RNA (Danio rerio)

- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - mRNA Splicing (Danio rerio)
    - mRNA Splicing - Major Pathway (Danio rerio)
      - Formation of the Spliceosomal P complex and exon ligation (Danio rerio)
        
        Spliceosomal C* complex [nucleoplasm] (Danio rerio)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
        
        Spliceosomal P complex [nucleoplasm] (Danio rerio)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Danio rerio)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
- mRNA Capping (Danio rerio)
  - Activation of GT (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - Capping complex formation (Danio rerio)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Capping complex (initial) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - Dissociation of transcript with 5'-GMP from GT (Danio rerio)
    - Capping complex (GpppN..) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - Formation of the CE:GMP intermediate complex (Danio rerio)
    - Capping complex (intermediate) [nucleoplasm] (Danio rerio)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Danio rerio)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Capping complex (hydrolyzed) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Danio rerio)
    - Capping complex (hydrolyzed) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Capping complex (initial) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Danio rerio)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Danio rerio)
    - Capping complex (intermediate) [nucleoplasm] (Danio rerio)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Danio rerio)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)
    - Capping complex (GpppN..) [nucleoplasm] (Danio rerio)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Danio rerio)
        
        TFIIF [nucleoplasm] (Danio rerio)
        
        zgc:110187 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q568N8

Gene Names

zgc:110187

Reference Genes

BioGPS Gene:100148942 zgc:110187

ENSEMBL:ENSDARG00000006816

KEGG Gene (Danio rerio):100148942 zgc:110187

Monarch:100148942 zgc:110187

NCBI Gene:100148942 zgc:110187

Reference Transcript

RefSeq:NM_001017832.1 zgc:110187

Participates

as a component of

TFIIF [nucleoplasm] (Danio rerio)

Inferred From

GTF2F2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001017832.1

ZFIN

ZDB-GENE-050417-374

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