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xpa [nucleoplasm]
Stable Identifier
R-DRE-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
nucleoplasm
Synonyms
XPA, Q7SY02
Locations in the PathwayBrowser
Expand all
DNA Repair (Danio rerio)
Nucleotide Excision Repair (Danio rerio)
Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
Dual Incision in GG-NER (Danio rerio)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Formation of Incision Complex in GG-NER (Danio rerio)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
CHD1L is recruited to GG-NER site (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
Dual incision in TC-NER (Danio rerio)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
TC-NER incision complex [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
TC-NER incision complex [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Formation of TC-NER Pre-Incision Complex (Danio rerio)
UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
xpa [nucleoplasm] (Danio rerio)
External Reference Information
External Reference
UniProt:Q7SY02
Gene Names
xpa
Reference Genes
BioGPS Gene:393443 xpa
ENSEMBL:ENSDARG00000038114
KEGG:dre:393443 xpa
Monarch:393443 xpa
NCBI Gene:393443 xpa
UCSC:Q7SY02 xpa
Reference Transcript
RefSeq:NM_200471.1 xpa
Participates
as a component of
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Danio rerio)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Danio rerio)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
ZFIN
ZDB-GENE-040426-1205
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