Reactome | zgc:65936 [cytosol]

zgc:65936 [cytosol]

Stable Identifier

R-DRE-72325

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS10, Q7T1J9

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        zgc:65936 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T1J9

Gene Names

zgc:65936

Reference Genes

BioGPS Gene:394121 zgc:65936

ENSEMBL:ENSDARG00000034897

ENSEMBL:ENSDARG00000034897.10 zgc:65936

KEGG Gene (Danio rerio):394121 zgc:65936

Monarch:394121 zgc:65936

NCBI Gene:394121 zgc:65936

Reference Transcript

RefSeq:NM_201146.1 zgc:65936

Other Identifiers

13224066

394121

A_15_P118389

DRER05577

DRER47542

DRER47989

Dr.25291.2.A1_at

ENSDART00000045901

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0022627

GO:0043226

GO:0048856

GT_Spec_NM_201146.1_182415

LOLS06158

NM_201146

ZV700S00004388

Participates

as a component of

40S ribosomal complex [cytosol] (Danio rerio)

Other forms of this molecule

zgc:65936 [nucleoplasm]

Inferred From

RPS10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_957440.1

ZFIN

ZDB-GENE-040426-1481

Ensembl

ENSDARP00000045900, ENSDARG00000034897, ENSDART00000164283, ENSDART00000045901, ENSDARP00000134332

PDB

7OYA, 7OYB

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