Reactome | fa95a02 [cytosol]

fa95a02 [cytosol]

Stable Identifier

R-DRE-72329

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS12, Q6PC90

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        fa95a02 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PC90

Gene Names

fa95a02

Reference Genes

BioGPS Gene:337007 fa95a02

ENSEMBL:ENSDARG00000036875

ENSEMBL:ENSDARG00000036875.7 fa95a02

ENSEMBL:ENSDARG00000115157.1 fa95a02

KEGG Gene (Danio rerio):337007 fa95a02

Monarch:337007 fa95a02

NCBI Gene:337007 fa95a02

Reference Transcript

Other Identifiers

13135183

337007

A_15_P109570

BC059433

CUST_19532_PI428451953

CUST_65_PI428451961

DRER06730

DRER37396

Dr.1202.2.S1_at

ENSDART00000053542

ENSDART00000053542_1

ENSDART00000053542_2

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022627

GO:0043226

GO:0110165

GO:1990904

GT_Xhyb_NM_001282177.1_187815

GT_Xhyb_NM_200046.3_187825

LOLS15036

MADDr01007718

OTTDART00000027031

OTTDART00000027032

XM_682359

Participates

as a component of

40S ribosomal complex [cytosol] (Danio rerio)

Other forms of this molecule

fa95a02 [nucleoplasm]

Inferred From

RPS12 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_956340.1, NP_001269106.1

ZFIN

ZDB-GENE-030131-8951

Ensembl

ENSDARG00000036875, ENSDARP00000053541, ENSDARP00000120403, ENSDART00000138350, ENSDARG00000115157, ENSDART00000053542, ENSDARP00000152860, ENSDART00000187214

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