Reactome | rps16 [cytosol]

rps16 [cytosol]

Stable Identifier

R-DRE-72337

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS16, Q1LWH1

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)
- rRNA processing (Danio rerio)
  - rRNA processing in the nucleus and cytosol (Danio rerio)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Danio rerio)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps16 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q1LWH1

Gene Names

rps16

Reference Genes

BioGPS Gene:767765 rps16

ENSEMBL:ENSDARG00000045487

KEGG:dre:767765 rps16

Monarch:767765 rps16

NCBI Gene:767765 rps16

UCSC:Q1LWH1 rps16

Reference Transcript

RefSeq:NM_001076732.2 rps16

Other Identifiers

12916849

12916851

12916853

12917327

12917329

12917331

12923371

12923373

12923375

13188950

767765

A_15_P151141

A_15_P218026

A_15_P532942

A_15_P753661

DRER09549

DRER33086

Dr.953.2.S1_at

ENSDART00000066898

ENSDART00000066898_1

ENSDART00000066898_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GT_Xhyb_NM_001076732.2_422065

GT_Xhyb_XM_005164903.1_409945

LOLS04410

MADDr01006148

NM_001076732

OTTDART00000014901

Participates

as a component of

Other forms of this molecule

rps16 [nucleoplasm]

Inferred From

RPS16 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001070200.1

ENSEMBL

ENSDART00000066898, ENSDARP00000144303, ENSDARP00000066897, ENSDARG00000045487, ENSDART00000174400

ZFIN

ZDB-GENE-050506-107

PDB

7OYB, 7OYA

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