Reactome | rps28 [cytosol]

rps28 [cytosol]

Stable Identifier

R-DRE-72365

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPS28, Q6PBK3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        40S ribosomal complex [cytosol] (Danio rerio)
        
        rps28 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBK3

Gene Names

rps28

Reference Genes

BioGPS Gene:406307 rps28

ENSEMBL:ENSDARG00000035860

KEGG Gene (Danio rerio):406307 rps28

Monarch:406307 rps28

NCBI Gene:406307 rps28

Reference Transcript

RefSeq:NM_213034.3 rps28

Other Identifiers

13088633

406307

A_15_P106486

A_15_P327086

A_15_P630501

CUST_17452_PI428451953

CUST_9966_PI428451958

DRER06411

DRER32694

DRER52737

ENSDART00000052063

ENSDART00000052063_1

ENSDART00000052063_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

GT_Xhyb_NM_213034.2_10641

GT_Xhyb_XM_005171228.1_182135

MADDr01007065

NM_213034

OTTDART00000027467

OTTDART00000027469

Participates

as a component of

40S ribosomal complex [cytosol] (Danio rerio)

Other forms of this molecule

rps28 [nucleoplasm]

Inferred From

RPS28 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_998199.1

ZFIN

ZDB-GENE-030131-2022

Ensembl

ENSDART00000052063, ENSDARG00000035860, ENSDART00000133109, ENSDARP00000115796, ENSDARP00000052062

PRO

Q6PBK3

PDB

7OYB, 7OYA

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