Reactome | rpl27 [cytosol]

rpl27 [cytosol]

Stable Identifier

R-DRE-72440

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL27, Q7ZV82

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        rpl27 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7ZV82

Gene Names

rpl27

Reference Genes

BioGPS Gene:325618 rpl27

ENSEMBL:ENSDARG00000015128

KEGG Gene (Danio rerio):325618 rpl27

Monarch:325618 rpl27

NCBI Gene:325618 rpl27

Reference Transcript

RefSeq:NM_199724.1 rpl27

Other Identifiers

13175092

325618

A_15_P110399

A_15_P663061

CUST_19722_PI428451953

DRER02565

DRER39358

Dr.24671.1.S1_at

ENSDART00000020311

ENSDART00000020311_1

ENSDART00000020311_2

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

GT_Spec_XM_005163928.1_55957

GT_Xhyb_NM_199724.1_363745

LOLS10773

MADDr01007265

NM_199724

OTTDART00000024718

OTTDART00000024719

Participates

as a component of

Inferred From

RPL27 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_956018.1

ZFIN

ZDB-GENE-030131-4343

Ensembl

ENSDART00000020311, ENSDARP00000018737, ENSDARP00000117864, ENSDARG00000015128, ENSDART00000140518

PRO

Q7ZV82

PDB

7OYB, 7OYA

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