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pik3ca [cytosol]
Stable Identifier
R-DRE-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
PIK3CA, F1QAD7
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Cell surface interactions at the vascular wall (Danio rerio)
Tie2 Signaling (Danio rerio)
Interaction of Tie2 and p85 of PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
p85 bound to Tie2 [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
GPVI-mediated activation cascade (Danio rerio)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Danio rerio)
PI3K alpha, beta, gamma [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
K63polyUb-PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Phospholipid metabolism (Danio rerio)
PI Metabolism (Danio rerio)
Synthesis of PIPs at the plasma membrane (Danio rerio)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Danio rerio)
PIK3C(1) [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Danio rerio)
PIK3(2) [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
Negative regulation of the PI3K/AKT network (Danio rerio)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activator:PI3K [plasma membrane] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
RAC1,RAC2,RHOG activate PI3K (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS:GTP binds PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
p21 RAS:GTP:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
G alpha (q) inhibits PI3K alpha (Danio rerio)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by Nuclear Receptors (Danio rerio)
ESR-mediated signaling (Danio rerio)
Extra-nuclear estrogen signaling (Danio rerio)
PI3K binds membrane-associated estrogen receptors (Danio rerio)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
Active ALK recruits PI3K (Danio rerio)
Active ALK:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K synthesizes PIP3 downstream of ALK (Danio rerio)
Active ALK:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by EGFR (Danio rerio)
GAB1 signalosome (Danio rerio)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Danio rerio)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
PI3K events in ERBB2 signaling (Danio rerio)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
PI3K events in ERBB4 signaling (Danio rerio)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Downstream signaling of activated FGFR1 (Danio rerio)
PI-3K cascade:FGFR1 (Danio rerio)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by LTK (Danio rerio)
Active LTK receptor binds PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
PI3-kinase binds to the active receptor (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Direct recruitment of PI3K to p-KIT (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Danio rerio)
PI3K [cytosol] (Danio rerio)
PI3K-catalytic subunit [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
Signaling by Rho GTPases (Danio rerio)
RHO GTPase cycle (Danio rerio)
RAC2 GTPase cycle (Danio rerio)
RAC2 binds effectors at the plasma membrane (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Danio rerio)
RAC2 plasma membrane effectors [cytosol] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
pik3ca [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:F1QAD7
Gene Names
pik3ca
Reference Genes
BioGPS Gene:561737 pik3ca
ENSEMBL:ENSDARG00000075456
KEGG:dre:561737 pik3ca
Monarch:561737 pik3ca
NCBI Gene:561737 pik3ca
UCSC:F1QAD7 pik3ca
Reference Transcript
RefSeq:XM_021479874.1 pik3ca
RefSeq:XM_005155854.3 pik3ca
RefSeq:XM_017358348.1 pik3ca
RefSeq:XM_009306177.3 pik3ca
RefSeq:XM_009306176.3 pik3ca
Other Identifiers
12980854
13275690
561737
A_15_P267271
A_15_P352465
CJ011331
CJ012389
CJ012664
CJ013233
CJ013304
CJ013387
CJ013995
CJ014464
CUST_1359_PI428451953
CUST_29600_PI428451953
DRER20523
ENSDART00000112973
GO:0003824
GO:0005737
GO:0005886
GO:0005943
GO:0005944
GO:0006629
GO:0016301
GO:0016303
GO:0016740
GO:0035005
GO:0036092
GO:0043491
GO:0046854
GO:0046934
GO:0048015
GO:0048696
GT_Xhyb_XM_002663811.2_328365
GT_Xhyb_XM_005174426.1_354635
JP011533
LOL01537
LOL02044
LOL04811
LOL04812
LOL04813
LOL04814
LOL04815
LOL04816
LOL04817
LOL05351
XM_685143
Participates
as a component of
K63polyUb-PI3K alpha [cytosol] (Danio rerio)
PIK3CA:PIK3R3 [cytosol] (Danio rerio)
PIK3CA:PIK3R2 [cytosol] (Danio rerio)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Danio rerio)
PI3K alpha [cytosol] (Danio rerio)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
PIK3CA:PIK3R1 [cytosol] (Danio rerio)
as a member of
PI3K-catalytic subunit [cytosol] (Danio rerio)
Inferred From
PIK3CA [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017213837.1
,
XP_021335549.1
,
XP_009304452.1
,
XP_009304451.1
,
XP_005155911.1
ENSEMBL
ENSDART00000158616
,
ENSDART00000114004
,
ENSDARP00000103176
,
ENSDARP00000138914
,
ENSDART00000188223
,
ENSDARP00000148626
ZFIN
ZDB-GENE-130409-1
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