Reactome | ube2s [nucleoplasm]

ube2s [nucleoplasm]

Stable Identifier

R-DRE-8852051

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

UBE2S, Q4V908

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle, Mitotic (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        APC/C:Cdh1 polyubiquitinates SKP2 (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        RB1 recruits APC/C:Cdh1 complex to SKP2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        Phosphorylation of the APC/C (Danio rerio)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Free APC/C phosphorylated by Plk1 (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Danio rerio)
        
        Degradation of multiubiquitinated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Multiubiquitination of APC/C-associated Cdh1 (Danio rerio)
        
        multiubiquitinated Cdh1 associated with APC/C [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Dissociation of phospho-Cdh1 from the APC/C complex (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular Senescence (Danio rerio)
    - Senescence-Associated Secretory Phenotype (SASP) (Danio rerio)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Danio rerio)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C complex binds EHMT1:EHMT2 (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
      - Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Danio rerio)
        
        EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)
        
        Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Danio rerio)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Protein ubiquitination (Danio rerio)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Danio rerio)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Danio rerio)
        
        E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Danio rerio)
        
        ube2s [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q4V908

Gene Names

ube2s

Reference Genes

BioGPS Gene:565498 ube2s

ENSEMBL:ENSDARG00000031775

KEGG Gene (Danio rerio):565498 ube2s

Monarch:565498 ube2s

NCBI Gene:565498 ube2s

Reference Transcript

RefSeq:NM_001025536.1 ube2s

Other Identifiers

13037045

13037048

565498

A_15_P113384

A_15_P175826

CJ012206

CJ012207

CUST_11817_PI428451958

DRER05776

DRER40621

Dr.14654.1.S1_at

Dr.17970.1.S1_at

ENSDART00000047452

ENSDART00000047452_1

ENSDART00000047452_2

ENSDART00000111544

GT_Spec_NM_001025536.1_311765

LOLS09394

MADDr01001921

TC240614

XM_683209

XM_703975

ZV700S00002697

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Danio rerio)

as a component of

phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Danio rerio)

Other forms of this molecule

ube2s [cytosol]

ube2s [nucleoplasm]

ube2s [cytosol]

Inferred From

UBE2S [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001020707.1

Ensembl

ENSDARP00000047451, ENSDART00000047452, ENSDARG00000031775

PRO

Q4V908

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