Reactome | scarb2b [clathrin-coated endocytic vesicle membrane]

scarb2b [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DRE-8869106

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SCARB2, A0A2R8Q7M1

Locations in the PathwayBrowser

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Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        scarb2b [clathrin-coated endocytic vesicle membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A2R8Q7M1

Gene Names

scarb2b

Reference Genes

BioGPS Gene:564077 scarb2b

CTD Gene:564077 scarb2b

ENSEMBL:ENSDARG00000100753

KEGG Gene (Danio rerio):564077 scarb2b

Monarch:564077 scarb2b

NCBI Gene:564077 scarb2b

Reference Transcript

RefSeq:XM_009301636.2 scarb2b

Other Identifiers

13112936

564077

A_15_P135126

A_15_P214466

A_15_P339730

A_15_P349540

A_15_P396600

CJ000247

CUST_2496_PI428451953

DRER12305

ENSDART00000082375

ENSDART00000082375_1

ENSDART00000082375_2

GO:0003674

GO:0005044

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0016020

GO:0043226

GT_Spec_XM_003200802.2_219345

JP000247

XM_687433

Participates

as a member of

Homologues of SCARB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Other forms of this molecule

scarb2b [plasma membrane]

Inferred From

SCARB2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_009299911.1

Ensembl

ENSDARG00000100753, ENSDARP00000149103, ENSDART00000184345

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