Reactome | caiap [cytosol]

caiap [cytosol]

Stable Identifier

R-DRE-975417

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ASB10, Q5TYM7

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Danio rerio)
        
        ASB family [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Danio rerio)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Danio rerio)
        
        CUL5-box protein [cytosol] (Danio rerio)
        
        caiap [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5TYM7

Gene Names

caiap

Reference Genes

BioGPS Gene:557416 caiap

ENSEMBL:ENSDARG00000092758

Monarch:557416 caiap

NCBI Gene:557416 caiap

Reference Transcript

RefSeq:NM_001025492.1 caiap

Other Identifiers

13094938

557416

A_15_P168756

CUST_9691_PI428451958

DRER39120

ENSDART00000063914

ENSDART00000063914_1

ENSDART00000063914_2

GO:0005515

GO:0012501

GO:0042981

GT_Spec_NM_001025492.1_124256

MADDr01005539

NM_001025492

OTTDART00000010375

Participates

as a member of

Other forms of this molecule

caiap [cytosol]

Inferred From

ASB10 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020663.1

ZFIN

ZDB-GENE-041014-19

Ensembl

ENSDART00000140250, ENSDARG00000092758, ENSDARP00000115713

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