TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex

Stable Identifier
Reaction [omitted]
Gallus gallus
Related Species
Infectious bronchitis virus
Locations in the PathwayBrowser
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TRAFs are E3 ubiquitin ligases that catalyse Lys63-polyubquitination of associated target proteins and possibly on themselves.
Virus- triggered Lys63-polyubiquitination of TRAF3/ or TRAF6 was shown to be essential for induction of IFN production [Mao AP et al 2010]. Furthermore, Kayagaki et al. demonstrated that deubiquitinating enzyme A (DUBA) specifically removed Lys63-linked polyubiquitin chains from TRAF3, resulting in its dissociation from the IFN signaling complex [Kayagaki N et al 2007].

Literature References
PubMed ID Title Journal Year
19465916 E2 interaction and dimerization in the crystal structure of TRAF6

Yin, Q, Lin, SC, Lamothe, B, Lu, M, Lo, YC, Hura, G, Zheng, L, Rich, RL, Campos, AD, Myszka, DG, Lenardo, MJ, Darnay, BG, Wu, H

Nat Struct Mol Biol 2009
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Lamothe, B, Besse, A, Campos, AD, Webster, WK, Wu, H, Darnay, BG

J Biol Chem 2007
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Xia, ZP, Sun, L, Chen, X, Pineda, G, Jiang, X, Adhikari, A, Zeng, W, Chen, ZJ

Nature 2009
Catalyst Activity

ubiquitin-ubiquitin ligase activity of dsRNA:MDA5:IPS1:TRAF3/ or TRAF6 [mitochondrial outer membrane]

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