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phospho-p-Y542,Y580-PTPN11 [cytosol]
Stable Identifier
R-GGA-162573
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q90687
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
PTPN11 is phosphorylated (Gallus gallus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
FRS-mediated FGFR1 signaling (Gallus gallus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
PI-3K cascade:FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Negative regulation of FGFR1 signaling (Gallus gallus)
CBL ubiquitinates FRS2 and FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
FRS-mediated FGFR2 signaling (Gallus gallus)
Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
PI-3K cascade:FGFR2 (Gallus gallus)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Negative regulation of FGFR2 signaling (Gallus gallus)
CBL ubiquitinates FRS2 and FGFR2 (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
FRS-mediated FGFR3 signaling (Gallus gallus)
Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
PI-3K cascade:FGFR3 (Gallus gallus)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Negative regulation of FGFR3 signaling (Gallus gallus)
CBL ubiquitinates FRS2 and FGFR3 (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
FRS-mediated FGFR4 signaling (Gallus gallus)
Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Gallus gallus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
PI-3K cascade:FGFR4 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Negative regulation of FGFR4 signaling (Gallus gallus)
CBL ubiquitinates FRS2 and FGFR4 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Gallus gallus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by Insulin receptor (Gallus gallus)
Insulin receptor signalling cascade (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Indirect recruitment of GAB2 to p-KIT (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Phosphorylation of GAB2 by SFKs (Gallus gallus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Phosphorylation of SHP2 by SFKs (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Gallus gallus)
IGF1R signaling cascade (Gallus gallus)
IRS-related events triggered by IGF1R (Gallus gallus)
IRS-mediated signalling (Gallus gallus)
PI3K Cascade (Gallus gallus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Gallus gallus)
PI3K-containing complexes [cytosol] (Gallus gallus)
Activated FGFR bound to PI3K [cytosol] (Gallus gallus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q90687
Reference Genes
BioGPS Gene:395815
ENSEMBL:ENSGALG00010020701
KEGG:gga:395815
Monarch:395815
NCBI Gene:395815
UCSC:Q90687
Reference Transcript
RefSeq:NM_204968.2
Other Identifiers
395815
GO:0000077
GO:0001784
GO:0003013
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005634
GO:0005737
GO:0005829
GO:0006470
GO:0006629
GO:0006641
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0019901
GO:0021697
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0031666
GO:0032331
GO:0032480
GO:0032481
GO:0032528
GO:0032728
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035855
GO:0036302
GO:0038127
GO:0042130
GO:0042311
GO:0042445
GO:0042593
GO:0043254
GO:0043408
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050839
GO:0051428
GO:0051463
GO:0051897
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0070374
GO:0071260
GO:0071364
GO:0140096
GO:1902533
GO:1902564
GO:1990782
GT_A_87_P009085
GT_A_87_P087218
Gga.482.1.S1_at
Participates
as a component of
p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Gallus gallus)
Other forms of this molecule
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
Inferred From
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 542 (in Homo sapiens)
Coordinate
542
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 580 (in Homo sapiens)
Coordinate
580
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_990299.1
ENSEMBL
ENSGALP00010029554
,
ENSGALG00010020701
,
ENSGALT00010050025
PRO
Q90687
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